| Gene Symbol |
Polr2a
|
| Entrez Gene |
20020
|
| Alt Symbol |
220kDa, Rpb1, Rpo2-1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) II (DNA directed) polypeptide A
|
| Other Description |
DNA-directed RNA polymerase II subunit A|DNA-directed RNA polymerase II subunit RPB1|DNA-directed RNA polymerase III largest subunit|RNA polymerase II 1|RNA polymerase II subunit B1
|
| Swissprots |
Q5F298 P08775
|
| Accessions |
AAA40071 P08775 AK051012 AK154270 AK154389 AK155391 AK170834 BAE42062 BC114996 U37500 AAB58418 NM_009089 NM_001291068 NP_001277997
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA h
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Huntington's disease, Herpes simplex infection, Epstein-Barr virus infection, Purine metabolism, RNA polymerase
|
