Polr2a

Gene Symbol Polr2a
Entrez Gene 20020
Alt Symbol 220kDa, Rpb1, Rpo2-1
Species Mouse
Gene Type protein-coding
Description polymerase (RNA) II (DNA directed) polypeptide A
Other Description DNA-directed RNA polymerase II subunit A|DNA-directed RNA polymerase II subunit RPB1|DNA-directed RNA polymerase III largest subunit|RNA polymerase II 1|RNA polymerase II subunit B1
Swissprots Q5F298 P08775
Accessions AAA40071 P08775 AK051012 AK154270 AK154389 AK155391 AK170834 BAE42062 BC114996 U37500 AAB58418 NM_009089 NM_001291068 NP_001277997
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA h
Subcellular Location Nucleus.
Top Pathways Huntington's disease, Herpes simplex infection, Epstein-Barr virus infection, Purine metabolism, RNA polymerase

Mouse Polr2a cDNA clone(NM_009089.2) - CDFL010540 from Creative Biomart

Species Mouse
Accession NM_009089.2

Mouse Polr2a ORF Clone(NM_009089.2) - CDCR382869 from Creative Biomart

Species Mouse
Accession NM_009089.2

Mouse Polr2a ORF Clone(NM_009089.2) - CDCR382870 from Creative Biomart

Species Mouse
Accession NM_009089.2

Mouse POLR2A ORF clone(NM_009089.2) - CDCG011255 from Creative Biomart

Species Mouse
Accession NM_009089.2

Mouse Polr2a ORF clone (NM_009089.2) - CDCH065890 from Creative biogene

Species Mouse

Mouse Polr2a cDNA Clone(NM_009089.2) - CDFL010540 from Creative biogene

Species Mouse
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