MERTK

Gene Symbol	MERTK
Entrez Gene	10461
Alt Symbol	MER, RP38, Tyro12, c-Eyk, c-mer
Species	Human
Gene Type	protein-coding
Description	MER proto-oncogene, tyrosine kinase
Other Description	MER receptor tyrosine kinase|STK kinase|c-mer proto-oncogene tyrosine kinase|proto-oncogene c-Mer|receptor tyrosine kinase MerTK|tyrosine-protein kinase Mer
Swissprots	Q9HBB4 Q12866
Accessions	AAK54121 AAX93144 AAY24213 EAW52096 EAW52097 Q12866 AK026681 AK294196 BAG57511 AK308695 AK316584 BAG38172 AL705756 AW627665 BC114917 AAI14918 BC114918 AAI14919 BM719997 BX474860 CA454601 CN371299 CN371300 D16316 BAA03823 U08023 AAB60430 XM_005263565 XP_005263622 XM_005263568 XP_005263625 XM_011510490 XP_011508792 XM_011510491 XP_011508793 NM_006343 NP_006334
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-Mer (panTyr) Sandwich ELISA Kit - 13340 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total Mer Sandwich ELISA Kit - 13488 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

MER Human ELISA Kit - ab119604 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 10 pg/ml Range 156 pg/ml - 10000 pg/ml

Human MER / MERTK ELISA Kit (Sandwich ELISA) - LS-F2690 from LifeSpan Bioscience Category ELISA Kit Prices $610.00 Sizes 1 plate Sensitivity 10 pg/ml Range 0.164-16 ng/ml

Mouse MER / MERTK ELISA Kit (Sandwich ELISA) - LS-F2691 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 10 pg/ml Range 0.164-16 ng/ml

Human MER / MERTK ELISA Kit (Sandwich ELISA) - LS-F462 from LifeSpan Bioscience Category ELISA Kit Prices $600.00, $1,100.00, $2,520.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.164 ng/ml Range 0.164-16 ng/ml

Human MER / MERTK ELISA Kit (Sandwich ELISA) - LS-F8050 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.113 ng/ml Range 0.164-16 ng/ml

Human MERTK / Tyrosine-protein Kinase Mer ELISA Kit - RAB0712 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt

MER/MERTK BioAssay™ ELISA Kit, Mouse - 143965 from USBiological Life Science Category ELISA Kit Sensitivity < 10 pg/ml Range 78pg/ml-5000pg/ml

Human Total Mer DuoSet IC ELISA - DYC891-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 312.00 - 20,000 pg/mL

Human Total Mer DuoSet IC, 5 Plate - DYC891-5 from R&D Systems Category ELISA Kit

Human Phospho-Mer DuoSet IC Economy Pack, 15 Plate - DYC2579E from R&D Systems Category ELISA Kit

Human Phospho-Mer DuoSet IC ELISA - DYC2579-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,395.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)

Human Phospho-Mer DuoSet IC, 5 Plate - DYC2579-5 from R&D Systems Category ELISA Kit

Mouse Mer DuoSet ELISA - DY591 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 78.10 - 5,000 pg/mL

Human Mer DuoSet ELISA - DY6488 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 156.00 - 10,000 pg/mL

Human Mer ELISA Kit - 55R-1758 from Fitzgerald Category ELISA Kit Prices $475.00 Sizes 1 kit

Human MERTK ELISA Kit - abx056265 from Abbexa Category ELISA Kit

Human MERTK ELISA Kit - abx152310 from Abbexa Category ELISA Kit Sensitivity 0.113 ng/ml Range 0.313 ng/ml - 20 ng/ml

C-Mer Proto Oncogene Tyrosine Kinase (MERTK), Human, ELISA Kit - SEE271Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.113ng/mL Range 0.312-20ng/mL

Mer, Human, ELISA Kit - PB-0810 from ARP American Research Products Category ELISA Kit Prices $479.00 Sizes 96 t Sensitivity < 10 pg/ml Range 156pg/ml-10000pg/ml

Tyrosine-protein kinase Mer (MERTK), Human, ELISA Kit - CSB-EL013706HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Tyrosine-protein kinase Mer, MERTK, Human, ELISA Kit - E1419h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

MERTK (Human) ELISA Kit - KA2005 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Human Mer ELISA - ELH-Mer from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 0.15 ng/ml Range 0.15 ng/ml - 40 ng/ml

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