MERTK
| Gene Symbol | MERTK |
|---|---|
| Entrez Gene | 10461 |
| Alt Symbol | MER, RP38, Tyro12, c-Eyk, c-mer |
| Species | Human |
| Gene Type | protein-coding |
| Description | MER proto-oncogene, tyrosine kinase |
| Other Description | MER receptor tyrosine kinase|STK kinase|c-mer proto-oncogene tyrosine kinase|proto-oncogene c-Mer|receptor tyrosine kinase MerTK|tyrosine-protein kinase Mer |
| Swissprots | Q9HBB4 Q12866 |
| Accessions | AAK54121 AAX93144 AAY24213 EAW52096 EAW52097 Q12866 AK026681 AK294196 BAG57511 AK308695 AK316584 BAG38172 AL705756 AW627665 BC114917 AAI14918 BC114918 AAI14919 BM719997 BX474860 CA454601 CN371299 CN371300 D16316 BAA03823 U08023 AAB60430 XM_005263565 XP_005263622 XM_005263568 XP_005263625 XM_011510490 XP_011508792 XM_011510491 XP_011508793 NM_006343 NP_006334 |
| Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1 |
| Subcellular Location | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Tissue Specificity | Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. |
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