ALOX5

Gene Symbol	ALOX5
Entrez Gene	240
Alt Symbol	5-LO, 5-LOX, 5LPG, LOG5
Species	Human
Gene Type	protein-coding
Description	arachidonate 5-lipoxygenase
Other Description	LOX-5|arachidonic 5-lipoxygenase alpha-10 isoform|arachidonic 5-lipoxygenase delta-10-13 isoform|arachidonic 5-lipoxygenase delta-13 isoform|arachidonic 5-lipoxygenase delta-p10 isoform|arachidonic acid 5-lipoxygenase|leukotriene A4 synthase
Swissprots	E5FPY7 B7ZLS0 E5FPY5 P09917 Q5JQ14 E5FPY8
Accessions	AAA59522 AAA63212 EAW86642 EAW86643 P09917 AB208946 BAD92183 AK225603 AK315223 AW403395 BC034464 BC040450 BC130332 AAI30333 BC132677 AAI32678 BC143985 AAI43986 BC143986 BM153780 BQ003253 HM592258 ADR30798 HM592259 ADR30799 HM592260 ADR30800 HM592261 ADR30801 HQ258335 ADR83089 J03571 AAA65450 J03600 AAA36183 JQ728550 AFH78150 XM_011539564 XP_011537866 XM_011546981 XP_011545283 NM_000698 NP_000689 NM_001256153 NP_001243082 NM_001256154 NP_001243083
Function	Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. {ECO:0000269|PubMed:21233389}.
Subcellular Location	Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
Top Pathways	Toxoplasmosis, Ovarian steroidogenesis, Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

5-LO CRISPR/Cas9 KO Plasmid (h) - sc-401239 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

5-LO HDR Plasmid (h) - sc-401239-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

5-LO Double Nickase Plasmid (h) - sc-401239-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

5-LO Double Nickase Plasmid (h2) - sc-401239-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

5-LO CRISPR Activation Plasmid (h) - sc-401239-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

5-LO CRISPR Activation Plasmid (h2) - sc-401239-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

5-LO Lentiviral Activation Particles (h) - sc-401239-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

5-LO Lentiviral Activation Particles (h2) - sc-401239-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

5-LO siRNA (h) - sc-29596 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

5-LO shRNA Plasmid (h) - sc-29596-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

5-LO shRNA (h) Lentiviral Particles - sc-29596-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

5-Lipoxygenase RNAi - H00000240-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU148691 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1785 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1785 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

ALOX5 siRNA (Human) - CRH0167 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ALOX5 - MBS8228580 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

5-LO CRISPR/Cas9 KO Plasmid (h2) - sc-401239-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

5-LO HDR Plasmid (h2) - sc-401239-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human Alox5 (NM_000698.3) - SHH235386 from Creative biogene Category siRNA Species Reactivities Human

Human ALOX5 siRNA - orb260669 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ALOX5 shRNA Plasmid (Human) - CHH0167 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ALOX5 miRNA 3'UTR clone - MiUTR1H-00317 from Creative biogene Species Reactivities Human

ALOX5 miRNA 3'UTR clone - MiUTR1H-00318 from Creative biogene Species Reactivities Human

ALOX5 miRNA 3'UTR clone - MiUTR3H-01330 from Creative biogene Species Reactivities Human

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