Notch2

Gene Symbol Notch2
Entrez Gene 18129
Alt Symbol AI853703, N2
Species Mouse
Gene Type protein-coding
Description notch 2
Other Description Motch B|Notch gene homolog 2|neurogenic locus notch homolog protein 2
Swissprots Q06008 Q60941 O35516
Accessions EDL38950 EDL38951 O35516 AK027963 AK155137 BAE33071 AK155666 BAE33376 AK157200 BC059256 AAH59256 BC172642 AAI72642 D32210 BAA22094 U31881 AAC52924 X68279 CAA48340 NM_010928 NP_035058
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. {ECO:0000250, ECO:0000269|PubMed:10393120, ECO:0000269|PubMed:18710934}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in the brain, liver, kidney, neuroepithelia, somites, optic vesicles and branchial arches, but not heart.
Top Pathways Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

Notch 2 (M-20) - sc-7423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Notch-2 Antibody [Unconjugated] - AF5196 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal

Notch-2 Antibody (605724) - MAB5196 from Novus Biologicals

Prices $249.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 605724
Flow Cytometry Notch-2 Antibody (605724)

Notch-2 Antibody (605724) [Allophycocyanin] - FAB5196A from Novus Biologicals

Host Rat
Clonality Monoclonal
Clone 605724

Notch-2 Antibody (605724) [PE] - FAB5196P from Novus Biologicals

Host Rat
Clonality Monoclonal
Clone 605724

Hamster ANTI NOTCH 2 Antibody (OASA11459) - OASA11459 from Aviva Systems Biology

Prices $355.00
Sizes 250 µg
Host Hamster
Clonality Monoclonal
Clone HMN2-35

Hamster ANTI NOTCH 2 Antibody (OASA11460) - OASA11460 from Aviva Systems Biology

Prices $160.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone HMN2-35

NOTCH2 antibody [HMN2-35] - GTX39545 from GeneTex

Prices $199.00
Sizes 100 μg
Host Hamster
Clonality Monoclonal
Clone HMN2-35

NOTCH2 antibody [HMN2-35] - GTX39546 from GeneTex

Prices $319.00
Sizes 250 μg
Host Hamster
Clonality Monoclonal
Clone HMN2-35

Notch 2 antibody - 70R-31091 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

APC anti-mouse Notch 2 Antibody - 130713 from Biolegend

Prices $135.00, $305.00
Sizes 25 µg, 100 µg
Host Hamster
Clone HMN2-35
Mouse Notch 2 transfected cells stained with HMN2-35 APC

PE anti-mouse Notch 2 Antibody - 130707 from Biolegend

Prices $150.00
Sizes 50 µg
Host Hamster
Clone HMN2-35
Mouse Notch-2 transfected cells stained with HMN2-35 PE

BD Pharmingen™ PE Rat anti-Mouse Notch2 - 562755 from BD Biosciences

Prices $215.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 16F11

Mouse NOTCH 2 Antibody - GWB-Q00787 from Genway Biotech

Prices $363.00
Sizes 250 µg
Host Hamster

Mouse NOTCH 2 Antibody - GWB-Q00788 from Genway Biotech

Prices $168.00
Sizes 100 µg
Host Hamster

NOTCH 2, Monoclonal Antibody - MBS219854 from MyBioSource

Prices $365.00
Sizes 250 µg
Host Hamster
Clonality Monoclonal
Clone HMN2-35

NOTCH 2, Monoclonal Antibody - MBS224718 from MyBioSource

Prices $240.00
Sizes 100 tests
Host Hamster
Clonality Monoclonal
Clone HMN2-35

NOTCH 2, Monoclonal Antibody - MBS219855 from MyBioSource

Prices $210.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone HMN2-35

Anti-NOTCH2 monoclonal antibody, clone HMN2-35 - CABT-49817HM from Creative Diagnostics

Host Hamster
Clonality Monoclonal
Clone HMN2-35

Armenian Hamster anti-Mouse Notch 2 Monoclonal antibody [clone INO3-46], R-PE-Conjugated - DCABY-613 from Creative Diagnostics

Host Hamster
Clonality Monoclonal
Clone INO3-46

Notch 2 Antibody | HMN2-35 - MCA5702GA from AbD Serotec

Prices $210.00, $315.00
Sizes 100 µg, 250 µg
Host Hamster
Clonality Monoclonal
Clone HMN2-35

NOTCH2 antibody - 70R-50140 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Notch-2 Antibody (605724) [Alexa Fluor (R) 405] - FAB5196V from Novus Biologicals

Prices $339.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 605724

BD OptiBuild™ BV650 Rat Anti-Mouse Notch2 - 745293 from BD Biosciences

Prices $350.00
Sizes 50 µg
Host Rat
Clone 16F11

BD OptiBuild™ BV786 Rat Anti-Mouse Notch2 - 744608 from BD Biosciences

Prices $350.00
Sizes 50 µg
Host Rat
Clone 16F11
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