Notch2

Gene Symbol Notch2
Entrez Gene 18129
Alt Symbol AI853703, N2
Species Mouse
Gene Type protein-coding
Description notch 2
Other Description Motch B|Notch gene homolog 2|neurogenic locus notch homolog protein 2
Swissprots Q06008 Q60941 O35516
Accessions EDL38950 EDL38951 O35516 AK027963 AK155137 BAE33071 AK155666 BAE33376 AK157200 BC059256 AAH59256 BC172642 AAI72642 D32210 BAA22094 U31881 AAC52924 X68279 CAA48340 NM_010928 NP_035058
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. {ECO:0000250, ECO:0000269|PubMed:10393120, ECO:0000269|PubMed:18710934}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in the brain, liver, kidney, neuroepithelia, somites, optic vesicles and branchial arches, but not heart.
Top Pathways Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

Notch 2 CRISPR/Cas9 KO Plasmid (m) - sc-421931 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 2 HDR Plasmid (m) - sc-421931-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 2 Double Nickase Plasmid (m) - sc-421931-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 2 Double Nickase Plasmid (m2) - sc-421931-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 2 CRISPR Activation Plasmid (m) - sc-421931-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 2 CRISPR Activation Plasmid (m2) - sc-421931-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 2 Lentiviral Activation Particles (m) - sc-421931-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 2 Lentiviral Activation Particles (m2) - sc-421931-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Notch 2 siRNA (m) - sc-40136 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Notch 2 shRNA Plasmid (m) - sc-40136-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Notch 2 shRNA (m) Lentiviral Particles - sc-40136-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN36581 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36581 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NOTCH2 siRNA (Mouse) - CRM2809 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse NOTCH2 (NM_010928.2) - SHH353832 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Notch2(NM_010928.2) - SHR008592 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse NOTCH2 siRNA - orb282285 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

NOTCH2 shRNA Plasmid (Mouse) - CHM2809 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

NOTCH2 miRNA 3'UTR clone - MiUTR1M-07749 from Creative biogene

Species Reactivities Mouse
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