CNOT2

Gene Symbol CNOT2
Entrez Gene 4848
Alt Symbol CDC36, HSPC131, NOT2, NOT2H
Species Human
Gene Type protein-coding
Description CCR4-NOT transcription complex, subunit 2
Other Description CCR4-NOT transcription complex subunit 2|CCR4-associated factor 2|negative regulator of transcription 2
Swissprots Q9NSX5 Q9P028 Q9NWR6 Q9H3E0 Q9NZN8
Accessions EAW97245 EAW97246 EAW97247 EAW97248 EAW97249 Q9NZN8 AA234384 AF044215 AAQ13426 AF113226 AAG39297 AF161480 AAF29095 AF180473 AAF29827 AK000662 BAA91313 AK095789 BAG53128 AK129966 BAC85263 AK307479 AK315715 BAG38074 AL137674 CAB70869 AY395696 AAR32245 BC002597 AAH02597 BC011826 AAH11826 BX641116 CAE46054 DA445519 DB038192 EU446948 ABZ92477 XM_006719429 XP_006719492 XM_006719430 XP_006719493 XM_006719432 XP_006719495 XM_006719433 XP_006719496 XM_011538399 XP_011536701 XM_011538400 XP_011536702 XM_011538401 XP_011536703 NM_001199302 NP_001186231 NM_001199303 NP_001186232 NM_014515 NP_055330 NR_037615
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21299754}. Nucleus {ECO:0000305|PubMed:21299754}.
Tissue Specificity Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:10637334}.
Top Pathways RNA degradation

CNOT2 CRISPR/Cas9 KO Plasmid (h) - sc-418411 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT2 HDR Plasmid (h) - sc-418411-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT2 Double Nickase Plasmid (h) - sc-418411-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT2 Double Nickase Plasmid (h2) - sc-418411-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT2 CRISPR Activation Plasmid (h) - sc-418411-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT2 CRISPR Activation Plasmid (h2) - sc-418411-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT2 Lentiviral Activation Particles (h) - sc-418411-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT2 Lentiviral Activation Particles (h2) - sc-418411-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT2 siRNA (h) - sc-72937 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CNOT2 shRNA Plasmid (h) - sc-72937-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CNOT2 shRNA (h) Lentiviral Particles - sc-72937-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CNOT2 RNAi - H00004848-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU001661 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6320 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6320 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CNOT2 siRNA (Human) - CRH3220 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CNOT2 - MBS826856 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CNOT2 (NM_014515.5) - SHH266425 from Creative biogene

Category siRNA
Species Reactivities Human

CNOT2 shRNA Plasmid (Human) - CHH3220 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CNOT2 miRNA 3'UTR clone - MiUTR3H-07196 from Creative biogene

Species Reactivities Human
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