FLT1

Gene Symbol FLT1
Entrez Gene 2321
Alt Symbol FLT, FLT-1, VEGFR-1, VEGFR1
Species Human
Gene Type protein-coding
Description fms-related tyrosine kinase 1
Other Description fms-like tyrosine kinase 1|fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)|tyrosine-protein kinase FRT|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular permeability factor receptor
Swissprots F5H5L6 B2BF48 A8KA71 A3E342 B0LPF1 B3FR89 O60722 P16057 A3E344 Q12954 B2BF46 B5A923 P17948 B2BF47
Accessions ABY87530 AGC09589 AGL73885 AGL73886 AGS56393 AGS56394 AHC08482 AHC08483 AHC08484 AHC08485 AHC08486 AHC08487 AHC08488 AHC08489 AHO49114 AHO49115 AHO49116 AHO49117 BAA00080 CAH56859 CAJ33638 CBW44131 EAX08431 EAX08432 P17948 AB209050 BAD92287 AF063657 AAC16449 AK092472 AK292936 BAF85625 AK300392 BAG62125 AK309901 BC029849 BC039007 AAH39007 BE180461 BU151621 BX504049 CA396081 DA844548 DA851664 DQ836394 ABI53803 DQ836395 ABI53804 DQ836396 ABI53805 EF484674 EF491868 ABS32268 EF491869 ABS32269 EF491870 ABS32270 EU360600 ACB05747 EU368830 ACA62948 EU443152 ACA21474 EU826561 ACF47597 EU826562 ACF47598 JF509744 AFC77954 JF509745 AFC77955 S77812 AAB34001 S77814 AAB34002 U01134 AAC50060 XM_011535014 XP_011533316 NM_001159920 NP_001153392 NM_001160030 NP_001153502 NM_001160031 NP_001153503 NM_002019 NP_002010
Function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane
Subcellular Location Isoform 7: Cytoplasm {ECO:0000305}.
Tissue Specificity Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC). {ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:20512933}.
Top Pathways Cytokine-cytokine receptor interaction, Focal adhesion, Endocytosis, Rheumatoid arthritis, PI3K-Akt signaling pathway

Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb - 3817 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5A6
Western blot analysis of PAE/CKR cells, untreated or stimulated with CSF-1, using Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb (upper) and VEGF Receptor 2 (55B11) Rabbit mAb #2479 (lower). PAE/CKR cells express a chimeric receptor made up of human CSF-1 receptor extracellular domain and mouse VEGF receptor 2 transmembrane and intracellular domains.

VEGF Receptor 1 Antibody - 2893 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from PAE cells transfected with either a mock expression vector or human VEGFR-1, using VEGF Receptor 1 Antibody.

Flt-1 (D-2) - sc-271789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Flt-1 (D-2): sc-271789. Western blot analysis of Flt-1 expression in non-transfected: sc-117752 (A) and human Flt-1 transfected: sc-115518 (B) 293T whole cell lysates.

Flt-1 (H-225) - sc-9029 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Flt-1 (H-225): sc-9029. Western blot analysis of Flt-1 expression in non-transfected: sc-117752 (A) and truncated human Flt-1 transfected: sc-115518 (B) 293T whole cell lysates.

Flt-1 (N-16) - sc-31173 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Flt-1 (N-16): sc-31173. Western blot analysis of Flt-1 expression in MDA-MB-231 whole cell lysate (A) and mouse embryo tissue extract (B).

Flt-1 (C-17) - sc-316 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Flt-1 (C-17)-G: sc-316-G. Western blot analysis of Flt-1 expression in A-10 whole cell lysate.

Anti-VEGF Receptor 1 (phospho Y1048) antibody - ab192802 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue labeling VEGF Receptor 1 (phospho Y1048) with ab192802 at 1/50 (left) or ab192802 preincubated with blocking peptide (right).

Anti-VEGF Receptor 1 (phospho Y1213) antibody - ab195762 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VEGF Receptor 1 (phospho Y1213) antibody (ab195762) at 1/500 dilutionLane 1 : UV treated HeLa whole cell lysates with the antigen-specific peptideLane 2 : UV treated HeLa whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-VEGF Receptor 1 antibody - ab2350 from Abcam

Prices $391.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab2350 - immunohistochemistry Formalin fixed paraffin embedded human angiosarcoma stained with VEGF Receptor 1, using ABC and AEC chromogen.

Anti-VEGF Receptor 1 antibody - ab59277 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab59277 at a dilution of 1/50. Left hand image - without immunising peptide. Right hand image - with immunising peptide.

Anti-VEGF Receptor 1 antibody - ab33025 from Abcam

Prices $372.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-VEGF Receptor 1 antibody - ab76777 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-VEGF Receptor 1 antibody - ab85142 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VEGF Receptor 1 antibody (ab85142) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 3 : T47D (Human ductal breast epithelial tumor cell line) Whole Cell Lysate (ab14899)Lane 4 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 5 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 6 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-VEGF Receptor 1 antibody - ab17544 from Abcam

Prices $368.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Radioimmunoassay standard curve using ab17544 and radiolabelled sFLT-1 peptide.

Anti-VEGF Receptor 1 antibody [AP-MAB0702] - ab56300 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone AP-MAB0702

Anti-VEGF Receptor 1 antibody [Flt-1/EWC] - ab9540 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Flt-1/EWC
Immunohistochemistry analysis (Formalin/PFA-fixed paraffin-embedded sections) of Human Placenta, Placental Bed and Decidua Parietalis. VEGF Receptor 1 (geen) was labelled with ab9540 and VEGF Receptor 2 (red) was labelled with ab2349. Yellow - where both VEGF Receptor 1 and VEGF Receptor 2 are expressed. DAPI was used for nuclei staining (blue).

Anti-VEGF Receptor 1 antibody [FLT1658] - ab190712 from Abcam

Prices $368.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone FLT1658

Anti-VEGF Receptor 1 antibody, prediluted - ab15294 from Abcam

Prices $378.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15294 staining human placenta by Immunohistochemistry (FFPE-sections).

Anti-VEGF Receptor 1 antibody [Y103] - ab32152 from Abcam

Prices $404.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y103
Overlay histogram showing A431 cells stained with ab32152 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab32152, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used a goat anti-rabbit DyLight® 488 goat (IgG, H+L) (ab96899) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-VEGF Receptor 1 antibody [Y103] (Alexa Fluor® 488) - ab195253 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y103
Overlay histogram showing A431 cells stained with ab195253 (red line). The cells were fixed with 4% formaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab195253, 1/50 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 488 used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control.Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.This antibody gave a positive signal in A431 fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-VEGF Receptor 1 antibody - BSA and Azide free - ab80838 from Abcam

Prices $376.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Anti-VEGF Receptor 1 antibody - BSA and Azide free (ab80838) at 10 µg/ml + Human cells-69 lysate

Anti-VEGFR 1+VEGFR 2 antibody - ab36844 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FLT1 / VEGFR1 Antibody (aa27-758, clone FLT12) - LS-C85125 from LifeSpan Bioscience

Prices $755.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone FLT12

Anti-FLT1 / VEGFR1 Antibody (C-Terminus) - LS-C86084 from LifeSpan Bioscience

Prices $650.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-FLT1 / VEGFR1 Antibody - LS-C88676 from LifeSpan Bioscience

Prices $280.00, $555.00, $930.00
Sizes 100 µg, 500 µl, 1 mg
Host Rabbit
Clonality Polyclonal
Search more