| Gene Symbol |
PAPSS1
|
| Entrez Gene |
9061
|
| Alt Symbol |
ATPSK1, PAPSS, SK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
3'-phosphoadenosine 5'-phosphosulfate synthase 1
|
| Other Description |
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1|PAPS synthase 1|PAPSS 1|SK 1|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1|sulfurylase kinase 1
|
| Swissprots |
O43252 Q9P1P9 O75332 O43841 Q9UE98 Q96FB1 Q96TF4
|
| Accessions |
AAC39894 AAF40235 AAY40925 AAY41043 EAX06210 O43252 AF016496 AAD09325 AF033026 AAC28429 AF105227 AAF40236 AK292774 BAF85463 AK297981 BAH12699 AU132232 BC011392 AAH11392 BC032513 AAH32513 BC040940 BC050627 AAH50627 BQ437924 BU517185 CR457028 CAG33309 DQ891043 ABM81969 DQ894222 ABM85148 Y10387 CAA71413 XM_011532400 XP_011530702 XM_011532401 XP_011530703 NM_005443 NP_005434
|
| Function |
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
|
| Tissue Specificity |
Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage.
|
| Top Pathways |
Sulfur metabolism, Purine metabolism, Selenocompound metabolism
|