PAPSS1

Gene Symbol PAPSS1
Entrez Gene 9061
Alt Symbol ATPSK1, PAPSS, SK1
Species Human
Gene Type protein-coding
Description 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Other Description 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1|PAPS synthase 1|PAPSS 1|SK 1|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1|sulfurylase kinase 1
Swissprots O43252 Q9P1P9 O75332 O43841 Q9UE98 Q96FB1 Q96TF4
Accessions AAC39894 AAF40235 AAY40925 AAY41043 EAX06210 O43252 AF016496 AAD09325 AF033026 AAC28429 AF105227 AAF40236 AK292774 BAF85463 AK297981 BAH12699 AU132232 BC011392 AAH11392 BC032513 AAH32513 BC040940 BC050627 AAH50627 BQ437924 BU517185 CR457028 CAG33309 DQ891043 ABM81969 DQ894222 ABM85148 Y10387 CAA71413 XM_011532400 XP_011530702 XM_011532401 XP_011530703 NM_005443 NP_005434
Function Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Tissue Specificity Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage.
Top Pathways Sulfur metabolism, Purine metabolism, Selenocompound metabolism

PAPSS1-Over-expression-Lysate - LY11700a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PAPSS1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PAPSS1 gene

PAPSS1 Overexpression Lysate (Native) - NBP2-07749 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg

PAPSS 1 (h): 293 Lysate - sc-111127 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Panoply™ Human PAPSS1 Knockdown Stable Cell Line - CSC-DC011292 from Creative biogene

Category Cell Line
Species Human
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