HLA-DMA

Gene Symbol HLA-DMA
Entrez Gene 3108
Alt Symbol D6S222E, DMA, HLADM, RING6
Species Human
Gene Type protein-coding
Description major histocompatibility complex, class II, DM alpha
Other Description HLA class II histocompatibility antigen, DM alpha chain|MHC class II antigen DMA|class II histocompatibility antigen, M alpha chain|really interesting new gene 6 protein
Swissprots P28067 Q29639 Q29640
Accessions AAA56993 AAA56994 AHW47929 AHW47946 AHW47963 AHW47980 BAA31432 CAA54169 CAA54170 CAA60781 EAX03658 EAX03659 EAX03660 P28067 AA649861 AK291858 BAF84547 AK298081 BAH12721 AU100342 BC011447 AAH11447 BC026279 AAH26279 CR450324 CAG29320 DQ892839 ABM83765 DQ896086 ABM87085 X62744 CAA44606 NM_006120 NP_006111
Function Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
Subcellular Location Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
Top Pathways Leishmaniasis, HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection

HLA-DMα CRISPR/Cas9 KO Plasmid (h) - sc-404576 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLA-DMα HDR Plasmid (h) - sc-404576-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLA-DMα Double Nickase Plasmid (h) - sc-404576-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLA-DMα Double Nickase Plasmid (h2) - sc-404576-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLA-DMα CRISPR Activation Plasmid (h) - sc-404576-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLA-DMα CRISPR Activation Plasmid (h2) - sc-404576-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLA-DMα Lentiviral Activation Particles (h) - sc-404576-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLA-DMα Lentiviral Activation Particles (h2) - sc-404576-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLA-DMα siRNA (h) - sc-42909 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HLA-DMα shRNA Plasmid (h) - sc-42909-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HLA-DMα shRNA (h) Lentiviral Particles - sc-42909-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HLA DMA RNAi - H00003108-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10129 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10129 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01557 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01557

HLA-DMA miRNA 3'UTR clone - MiUTR3H-01085 from Creative biogene

Species Reactivities Human
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