| Gene Symbol |
HIF1A
|
| Entrez Gene |
281814
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
|
| Other Description |
HIF-1 alpha|HIF-1-alpha|HIF1 alpha|HIF1-alpha|hypoxia-inducible factor 1 alpha|hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)|hypoxia-inducible factor 1-alpha
|
| Swissprots |
Q9XTA5
|
| Accessions |
DAA25052 Q9XTA5 AB018398 BAA78675 BC126622 AAI26623 NM_174339 NP_776764
|
| Function |
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250|UniProtKB:Q61221, ECO:0000255|PROSITE- ProRule:PRU00981}. Note=Colocalizes with HIF3A in the nucleus and speckles. Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. {ECO:0000250|UniProtKB:Q61221}.
|
| Top Pathways |
Renal cell carcinoma, Central carbon metabolism in cancer, Choline metabolism in cancer, Proteoglycans in cancer, mTOR signaling pathway
|