PARP2

Gene Symbol PARP2
Entrez Gene 10038
Alt Symbol ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2
Species Human
Gene Type protein-coding
Description poly (ADP-ribose) polymerase 2
Other Description ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2|ADP-ribosyltransferase diphtheria toxin-like 2|ADPRT-2|NAD(+) ADP-ribosyltransferase 2|hPARP-2|poly (ADP-ribose) polymerase family, member 2|poly (ADP-ribosyl) transferase-like 2|poly [ADP-ribose] polymerase 2|poly[ADP-ribose] synthase 2|poly[ADP-ribose] synthetase 2
Swissprots Q9UMR4 Q9NUV2 Q9Y6C8 Q8TEU4 Q9UGN5
Accessions AAL77437 CAC07442 EAW66476 EAW66477 EAW66478 Q9UGN5 AF085734 AAD29857 AJ236876 CAB41505 AJ236912 CAB65088 AK001980 BAA92017 AK290079 BAF82768 AK300971 BAG62594 BC172288 AAI72288 BU541261 DA354586 XM_005267247 XP_005267304 XM_011536311 XP_011534613 XM_011536312 XP_011534614 XR_943347 NM_001042618 NP_001036083 NM_005484 NP_005475
Function Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Subcellular Location Nucleus.
Tissue Specificity Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus.
Top Pathways Base excision repair

PARP-2 (A-18) - sc-30622 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PARP-2 (A-18): sc-30622. Western blot analysis of PARP-2 expression in non-transfected: sc-117752 (A) and mouse PARP-2 transfected: sc-122386 (B) 293T whole cell lysates.

PARP-2 (F-3) - sc-393310 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PARP-2 (F-3): sc-393310. Western blot analysis of PARP-2 expression in non-transfected: sc-117752 (A) and mouse PARP-2 transfected: sc-122386 (B) 293T whole cell lysates.

PARP-2 (F-8) - sc-393343 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PARP-2 (F-8): sc-393343. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

PARP-2 (T-13) - sc-30624 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PARP2 antibody - ab115620 from Abcam

Prices $384.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115620, at 2.5µg/ml, staining PARP2 in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-PARP2 antibody - ab93416 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PARP2 antibody (ab93416) at 1/250 dilution + 3T3 cell lysate

Anti-PARP2 antibody - ab93841 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PARP2 antibody (ab93841) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Pancreas (Human) Tissue Lysate - adult normal tissue (ab29816)Lane 3 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PARP2 antibody - ab77270 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-PARP2 antibody (ab77270) at 1 µg/ml + Human Spleen Lysate (in RIPA buffer) at 35 µg

Anti-PARP2 antibody [AT29G4] - ab177529 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AT29G4
Lane 1 : Anti-PARP2 antibody [AT29G4] (ab177529) at 1/500 dilutionLane 2 : Anti-PARP2 antibody [AT29G4] (ab177529) at 1/1000 dilutionLane 3 : Anti-PARP2 antibody [AT29G4] (ab177529) at 1/5000 dilutionLane 1 : HeLa cell lysateLane 2 : HeLa cell lysateLane 3 : HeLa cell lysateLysates/proteins at 40 µg per lane.Secondarygoat anti-mouse secondary antibody conjugated to HRPdeveloped using the ECL technique

Anti-PARP2 antibody [EPR12759(B)] - ab176330 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12759(B)
ab176330 staining PARP2 in human HeLa cells treated with bleomycin by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde and permeabilized with 0.5% Triton X-100 in PBS. Samples were incubated with primary antibody (1/200 in PBS) for 16 hours at 22°C. An Alexa Fluor® 488-conjugated goat anti-rabbit IgG polyclonal (1/200) was used as the secondary antibody. Counterstained with DAPI.See Abreview

Anti-PARP2 antibody - N-terminal - ab170610 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PARP2 antibody - N-terminal (ab170610) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

Anti-PARP2 Antibody (aa401-450) IHC-plus™ - LS-B1553 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PARP2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1553 concentration 5 ug/ml.

Anti-PARP2 Antibody (aa389-401) IHC-plus™ - LS-B3239 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-PARP2 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3239 concentration 5 ug/ml.

Anti-PARP2 Antibody (aa10-40, FITC) - LS-C265628 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP2 Antibody (aa10-40, Biotin) - LS-C265627 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP2 Antibody (aa10-40, Azide-free, HRP) - LS-C265629 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP2 Antibody (clone AT29G4) - LS-C200853 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AT29G4
Western Blot: The cell lysate of HeLa (40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PARP2 antibody (1:500 ~ 1:5000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Anti-PARP2 Antibody (aa10-40, PE) - LS-C265632 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP2 Antibody (aa9-41) - LS-C323798 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP2 Antibody (aa1-207) - LS-C345066 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP2 Antibody (aa481-530) - LS-C205650 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PARP2 antibody Western Blot of MCF7. Antibody dilution: 1 ug/ml.

Anti-PARP2 Antibody (aa10-40) - LS-C163372 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PARP2 Antibody western blot of mouse heart tissue lysates (35 ug/lane). The PARP2 antibody detected the PARP2 protein (arrow).

Anti-PARP2 Antibody (aa306-336) - LS-C163371 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PARP2 Antibody western blot of mouse heart tissue lysates (35 ug/lane). The PARP2 antibody detected the PARP2 protein (arrow).

Anti-PARP2 Antibody (aa43-59) - LS-C2848 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP2 Antibody (aa172-188) - LS-C2979 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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