| Gene Symbol |
PARP2
|
| Entrez Gene |
10038
|
| Alt Symbol |
ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly (ADP-ribose) polymerase 2
|
| Other Description |
ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2|ADP-ribosyltransferase diphtheria toxin-like 2|ADPRT-2|NAD(+) ADP-ribosyltransferase 2|hPARP-2|poly (ADP-ribose) polymerase family, member 2|poly (ADP-ribosyl) transferase-like 2|poly [ADP-ribose] polymerase 2|poly[ADP-ribose] synthase 2|poly[ADP-ribose] synthetase 2
|
| Swissprots |
Q9UMR4 Q9NUV2 Q9Y6C8 Q8TEU4 Q9UGN5
|
| Accessions |
AAL77437 CAC07442 EAW66476 EAW66477 EAW66478 Q9UGN5 AF085734 AAD29857 AJ236876 CAB41505 AJ236912 CAB65088 AK001980 BAA92017 AK290079 BAF82768 AK300971 BAG62594 BC172288 AAI72288 BU541261 DA354586 XM_005267247 XP_005267304 XM_011536311 XP_011534613 XM_011536312 XP_011534614 XR_943347 NM_001042618 NP_001036083 NM_005484 NP_005475
|
| Function |
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus.
|
| Top Pathways |
Base excision repair
|