WHSC1

Gene Symbol	WHSC1
Entrez Gene	7468
Alt Symbol	MMSET, NSD2, REIIBP, TRX5, WHS
Species	Human
Gene Type	protein-coding
Description	Wolf-Hirschhorn syndrome candidate 1
Other Description	IL5 promoter REII region-binding protein|histone-lysine N-methyltransferase NSD2|multiple myeloma SET domain containing protein type III|nuclear SET domain-containing protein 2|probable histone-lysine N-methyltransferase NSD2|trithorax/ash1-related protein 5
Swissprots	Q86V01 A7MCZ1 A2A2T2 Q4VBY8 Q9UPR2 Q9BZB4 A2A2T4 Q6IS00 O96028 O96031 Q672J1 Q9UI92 A2A2T3 D3DVQ2
Accessions	AAF23369 AAF23370 EAW82548 EAW82549 EAW82550 EAW82551 EAW82552 EAW82553 EAW82554 EAW82555 EAW82556 EAW82557 EAW82558 O96028 AB029013 BAA83042 AF071593 AAC24150 AF071594 AAC24151 AF083386 AAD19343 AF083387 AAD21770 AF083388 AAD21771 AF083389 AAD19344 AF083390 AAD19345 AF083391 AAD19346 AF330040 AAK00344 AI339675 AI695058 AJ007042 CAB45386 AK026939 AK289697 BAF82386 AY694128 AAU09264 BC020545 AAH20545 BC032731 BC052254 AAH52254 BC070176 AAH70176 BC094825 AAH94825 BC110899 BC141815 AAI41816 BC144464 BC152412 AAI52413 BC166668 AAI66668 BM982021 CX866583 DQ185035 XM_005248001 XP_005248058 XM_005248002 XP_005248059 XM_005248005 XP_005248062 XM_006713914 XP_006713977 XM_006713915 XP_006713978 XM_011513557 XP_011511859 XM_011513558 XP_011511860 XM_011513559 XP_011511861 XM_011513560 XP_011511862 NM_001042424 NP_001035889 NM_007331 NP_015627 NM_133330 NP_579877 NM_133331 NP_579878 NM_133334 NP_579889 NM_133335 NP_579890 NM_014919 NM_133332 NM_133333 NM_133336
Function	Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:18172012}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}. Chromosome {ECO:0000305}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9618163}.
Top Pathways	Lysine degradation, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human WHSC1/NSD2 protein fragment - ab198120 from Abcam Category Protein Prices $858.00 Sizes 50 µg Source E. coli Species Human

Human WHSC1/NSD2 full length protein - ab159810 from Abcam Category Protein Source Wheat germ Species Human

Human WHSC1/NSD2 protein fragment - ab198087 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

WHSC1 / NSD2 Antibody Blocking Peptide - LS-E4709 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WHSC1 / NSD2 Antibody Blocking Peptide - LS-E11831 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WHSC1 Recombinant Protein - H00007468-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

WHSC1-Antibody-C-term-Blocking-Peptide - BP17079b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NSD2 blocking peptide - GTX15964-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Goat anti WHSC1 antibody Immunizing peptide - orb17176 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

WHSC1 Blocking Peptide - 33R-4748 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WHSC1 - H00007468-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WHSC1 - H00007468-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WHSC1 fusion protein - ag18611 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

WHSC1 fusion protein - ag18831 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant MMSET / WHSC1 - SET protein - 31476 from ActiveMotif Category Protein Prices $395.00, $3,500.00 Sizes 50 µg, 1 mg Source E. coli Species Human

Recombinant MMSET / WHSC1 protein - 31453 from ActiveMotif Category Protein Prices $395.00, $3,800.00 Sizes 20 µg, 1 mg Source Baculovirus Species Human

Recombinant Human Wolf-Hirschhorn Syndrome Candidate 1, GST-tagged - WHSC1-429H from Creative Biomart Category Protein Source E.Coli .

Recombinant Human WHSC1, FLAG-tagged - WHSC1-57H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human Probable histone-lysine N-methyltransferase NSD2(WHSC1) ,parti - CSB-YP026107HU CSB-EP026107HU CSB-BP026107HU CSB-MP026107HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WHSC1 Protein - abx164081 from Abbexa Category Protein Species Human, Mouse

Probable histone-lysine N-methyltransferase NSD2 (WHSC1), partial, Recombinant Protein - MBS1081616 from MyBioSource Category Protein Prices $1,095.00, $1,095.00, $1,325.00, $1,325.00, $1,670.00, $1,670.00, $2,130.00, $2,130.00, $2,165.00, $3,295.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

WHSC1 / MMSET, Peptide - MBS425083 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Human WHSC1 protein, FLAG/His-tagged - WHSC1-185H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant Human WHSC1 Protein, His-tagged - WHSC1-144H from Creative Biomart Category Protein Source Insect cell Species Human

Recombinant Human WHSC1 Protein - WHSC1-145H from Creative Biomart Category Protein Source Insect cell Species Human

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