| Gene Symbol | EIF4EBP1 |
|---|---|
| Entrez Gene | 1978 |
| Alt Symbol | 4E-BP1, 4EBP1, BP-1, PHAS-I |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 4E binding protein 1 |
| Other Description | eIF4E-binding protein 1|eukaryotic translation initiation factor 4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1 |
| Swissprots | Q6IBN3 Q13541 B2R502 D3DSW8 |
| Accessions | CCW44094 EAW63341 EAW63342 Q13541 AB044548 BAB18650 AK312011 BAG34949 BC004459 AAH04459 BC058073 AAH58073 BF964628 BT007162 AAP35826 CR456769 CAG33050 DQ890570 ABM92187 DQ893731 ABM84657 L36055 AAA62269 NM_004095 NP_004086 |
| Function | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:7935836}. |
| Top Pathways | RNA transport, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway, ErbB signaling pathway |