EIF4EBP1

Gene Symbol	EIF4EBP1
Entrez Gene	1978
Alt Symbol	4E-BP1, 4EBP1, BP-1, PHAS-I
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 4E binding protein 1
Other Description	eIF4E-binding protein 1|eukaryotic translation initiation factor 4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1
Swissprots	Q6IBN3 Q13541 B2R502 D3DSW8
Accessions	CCW44094 EAW63341 EAW63342 Q13541 AB044548 BAB18650 AK312011 BAG34949 BC004459 AAH04459 BC058073 AAH58073 BF964628 BT007162 AAP35826 CR456769 CAG33050 DQ890570 ABM92187 DQ893731 ABM84657 L36055 AAA62269 NM_004095 NP_004086
Function	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:7935836}.
Top Pathways	RNA transport, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® 4E-BP1 siRNA I - 6414 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

4E-BP1 CRISPR/Cas9 KO Plasmid (h) - sc-400398 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

4E-BP1 HDR Plasmid (h) - sc-400398-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

4E-BP1 Double Nickase Plasmid (h) - sc-400398-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

4E-BP1 Double Nickase Plasmid (h2) - sc-400398-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

4E-BP1 CRISPR Activation Plasmid (h) - sc-400398-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

4E-BP1 CRISPR Activation Plasmid (h2) - sc-400398-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

4E-BP1 Lentiviral Activation Particles (h) - sc-400398-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

4E-BP1 Lentiviral Activation Particles (h2) - sc-400398-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

4E-BP1 siRNA (h) - sc-29594 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

4E-BP1 shRNA Plasmid (h) - sc-29594-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

4E-BP1 shRNA (h) Lentiviral Particles - sc-29594-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

4EBP1 RNAi - H00001978-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU150481 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1245 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1245 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04263 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04263

EIF4EBP1 siRNA (Human) - CRH1368 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EIF4EBP1 - MBS8233322 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

4E-BP1 CRISPR/Cas9 KO Plasmid (h2) - sc-400398-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

4E-BP1 HDR Plasmid (h2) - sc-400398-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human EIF4EBP1 (NM_004095.3) - SHH284681 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human EIF4EBP1(NM_004095.3) - SHH029855 from Creative biogene Category siRNA Species Reactivities Human

Human EIF4EBP1 siRNA - orb261870 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EIF4EBP1 shRNA Plasmid (Human) - CHH1368 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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