CDK1

Gene Symbol CDK1
Entrez Gene 983
Alt Symbol CDC2, CDC28A, P34CDC2
Species Human
Gene Type protein-coding
Description cyclin-dependent kinase 1
Other Description cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2, G1 to S and G2 to M|cell division protein kinase 1|p34 protein kinase
Swissprots O60764 P06493 A8K7C4 C9J497
Accessions AAM34793 EAW54204 EAW54205 EAW54206 EAW54207 EAW54208 EAW54209 EAW54210 P06493 AA459484 AK291939 BAF84628 AK295741 BAH12172 AM392583 CAL37461 AM393047 CAL37925 AM393287 CAL38165 AM393726 CAL38602 AW976143 BC014563 AAH14563 BC107750 AAI07751 BF685285 BG723076 BT007004 AAP35650 BU633268 CR933728 CAI46271 D88357 BAA26001 DA823877 X05360 CAA28963 Y00272 CAA68376 XM_005270303 XP_005270360 XM_006718082 XP_006718145 NM_001170406 NP_001163877 NM_001170407 NP_001163878 NM_001786 NP_001777 NM_033379 NP_203698 NM_001130829
Function Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, be
Subcellular Location Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin- B1. Accumulates in mitochondria in G2-arrested cells upon DNA- damage.
Tissue Specificity Isoform 2 is found in breast cancer tissues.
Top Pathways Cell cycle, p53 signaling pathway, Gap junction, Progesterone-mediated oocyte maturation, Oocyte meiosis

Phospho-cdc2 (Tyr15) (10A11) Rabbit mAb (PE Conjugate) - 14566 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 10A11
Flow cytometric analysis of Jurkat cells using Phospho-cdc2 (Tyr15) (10A11) Rabbit mAb (PE Conjugate) and DRAQ5 ® #4084, which labels DNA.

Phospho-cdc2 (Thr14) Antibody - 2543 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from hydroxyurea-treated HT29 cells, aphidicolin-treated HeLa cells, and asynchronous and mitotic CHO cells using Phospho-cdc2 (Thr14) Antibody.

Phospho-cdc2 (Thr161) Antibody - 9114 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cdc2 kinase treated with lambda protein phosphatase (lambda-PPase) for the indicated times, using Phospho-cdc2 (Thr161) Antibody.

Phospho-cdc2 (Tyr15) Antibody - 9111 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Saos cells, either untreated or treated with hydroxyurea or nocodazole, using Phospho-cdc2 (Tyr15) Antibody #9111.

Phospho-cdc2 (Tyr15) (10A11) Rabbit mAb - 4539 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 10A11
Western blot analysis of extracts from HeLa cells, untreated or hydroxyurea treated for 20 hours, using Phospho-cdc2 (Tyr15) (10A11) Rabbit mAb.

PathScan ® Multi-Target HCA DNA Damage Kit - 7101 from Cell Signaling Technology

Prices $689.00
Sizes 1 kit (8 x 140 µl)
Clonality Polyclonal
Signaling pathway for antibodies in the PathScan ® Multi-Target HCA DNA Damage Kit. Representative confocal immunofluorescent images display typical localization of the individual proteins in untreated (left) or treated (right) cells.

cdc2 (POH1) Mouse mAb - 9116 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone POH1
Western blot analysis of extracts from HeLa cells synchronized at various stages of the cell cycle, using cdc2 (POH1) Mouse mAb.

cdc2 Antibody - 9112 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

PhosphoPlus ® cdc2 (Tyr15) Antibody Kit - 9110 from Cell Signaling Technology

Clonality Polyclonal

Cdc2 p34 (17) - sc-54 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc2 p34 (17): sc-54. Western blot analysis of Cdc2 p34 expression in A-431 nuclear extract.

Cdc2 p34 (D-9) - sc-271315 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc2 p34 (D-9): sc-271315. Western blot analysis of Cdc2 p34 expression in K-562 (A), A-431 (B) and NAMALWA (C) whole cell lysates and HeLa (D) nuclear extract.

Cdc2 p34 (C-9) - sc-137034 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc2 p34 (C-9): sc-137034. Western blot analysis of Cdc2 p34 expression in K-562 (A), A-431 (B) and HL-60 (C) whole cell lysates.

Cdc2 p34 (C-19) - sc-954 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cdc2 p34 (C-19): sc-954. Immunoperoxidase staining of formalin-fixed, paraffin-embedded normal human skin showing nuclear localization.

Cdc2 p34 (F-5) - sc-166885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc2 p34 (F-5): sc-166885. Western blot analysis of Cdk2 expression in non-transfected 293T: sc-117752 (A), mouse Cdk2 transfected 293T: sc-119146 (B) and K-562 (C) whole cell lysates.

Cdc2 p34 (H-297) - sc-747 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Cdc2 p34 phosphorylation expression in HeLa whole cell lysates (A-C). Blots were probed with p-Cdc2 p34 (Thr 14/Tyr 15)-R: sc-12340-R preincubated with cognate phosphorylated (A) or cognate unphosphorylated (B) peptide and Cdc2 p34 (H-297): sc-747 (C).

Cdc2 p34 (F-10) - sc-166135 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc2 p34 (F-10): sc-166135. Western blot analysis of Cdc2 p34 expression in HeLa nuclear extract.

Cdc2 p34 (PSTAIRE) - sc-53 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cdc2 p34 (PSTAIRE): sc-53. Western blot analysis of Cdc2 p34 expression in HeLa nuclear extract (A) and MCF7 whole cell lysate (B).

Cdc2 p34 (B-5) - sc-137035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc2 p34 (B-5): sc-137035. Western blot analysis of Cdc2 p34 expression in K-562 (A), A-431 (B) and HL-60 (C) whole cell lysates.

Cdc2 p34 (B-6) - sc-8395 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc2 p34 (B-6): sc-8395. Western blot analysis of Cdc2 p34 expression in A-431 (A) and HeLa (B) nuclear extracts.

Cdc2 p34 (POH-1) - sc-51578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Cdc2 p34 (POH-1): sc-51578. Western blot analysis of Cdc2 p34 expression in HeLa (A) and K-562 (B) nuclear extracts and NAMALWA (C), MCF7 (D) and BJAB (E) whole cell lysates.

Cdc2 p34 (B322) - sc-56261 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Cdc2 p34 (B322): sc-56261. Western blot analysis of Cdc2 p34 expression in non-transfected 293T: sc-117752 (A), mouse Cdc2 p34 transfected 293T: sc-119124 (B) and K-562 (C) whole cell lysates.

p-Cdc2 p34 (Thr 161) - sc-12341 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Cdc2 p34 (Thr 161)-R: sc-12341-R. Western blot analysis of Cdc2 p34 phosphorylation in HeLa whole cell lysate.

p-Cdc2 p34 (Tyr 15) - sc-7989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot detection of Cdc2 p34 phosphorylation using Saos-2 cells treated with hydroxyurea. Blots were probed with Cdc2 p34 (B-6): sc-8395 (A), p-Cdc2 p34 (Tyr 15)-R: sc-7989-R preincubated with cognate phosphorylated peptide (B) and p-Cdc2 p34 (Tyr 15)-R: sc-7989-R pre-incubated with identical unphosphorylated peptide (C).

p-Cdc2 p34 (Thr 161) - sc-101654 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Cdc2 p34 (Thr 161): sc-101654. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear and cytoplasmic staining.

p-Cdc2 p34 (pY15.44) - sc-136014 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
p-Cdc2 p34 (pY15.44): sc-136014. Western blot analysis of Cdc2 p34 phosphorylation in untreated (A) and alkaline phosphatase-treated (B) Saos-2 whole cell lysates.
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