CDK1

Gene Symbol	CDK1
Entrez Gene	983
Alt Symbol	CDC2, CDC28A, P34CDC2
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 1
Other Description	cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2, G1 to S and G2 to M|cell division protein kinase 1|p34 protein kinase
Swissprots	O60764 P06493 A8K7C4 C9J497
Accessions	AAM34793 EAW54204 EAW54205 EAW54206 EAW54207 EAW54208 EAW54209 EAW54210 P06493 AA459484 AK291939 BAF84628 AK295741 BAH12172 AM392583 CAL37461 AM393047 CAL37925 AM393287 CAL38165 AM393726 CAL38602 AW976143 BC014563 AAH14563 BC107750 AAI07751 BF685285 BG723076 BT007004 AAP35650 BU633268 CR933728 CAI46271 D88357 BAA26001 DA823877 X05360 CAA28963 Y00272 CAA68376 XM_005270303 XP_005270360 XM_006718082 XP_006718145 NM_001170406 NP_001163877 NM_001170407 NP_001163878 NM_001786 NP_001777 NM_033379 NP_203698 NM_001130829
Function	Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, be
Subcellular Location	Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin- B1. Accumulates in mitochondria in G2-arrested cells upon DNA- damage.
Tissue Specificity	Isoform 2 is found in breast cancer tissues.
Top Pathways	Cell cycle, p53 signaling pathway, Gap junction, Progesterone-mediated oocyte maturation, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CDK1 + CCNB1 full length protein - ab104618 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human CDK1 + Cyclin-A1 full length protein - ab104617 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

CDK1 peptide - ab8008 from Abcam Category Peptide

Human CDK1 full length protein - ab158068 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CDK1 full length protein - ab187447 from Abcam Category Protein Prices $588.00 Sizes 50 µg Source Baculovirus infected insect cells Species Human

Human CDK1 full length protein - ab202615 from Abcam Category Protein Prices $429.00 Sizes 100 µg Source E. coli Species Human

Human CDK1 full length protein - ab64306 from Abcam Category Protein Prices $188.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human CDK1 protein fragment - ab158069 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CDK1 / CDC2 Antibody Blocking Peptide - LS-E3768 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E3769 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E3955 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E10547 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E10564 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E10565 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Blocking Peptide - LS-E7259 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E7261 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E21356 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E21357 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E9019 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK1 / CDC2 Antibody Blocking Peptide - LS-E9020 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDC2/CDK1 Recombinant Protein - H00000983-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CDC2/CDK1 Partial Recombinant Protein - H00000983-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CDC2/CDK1 Peptide - P0496 from Novus Biologicals Category Peptide Species Human

CDC2/CDK1 Peptide - P0497 from Novus Biologicals Category Peptide Species Human

CDC2/CDK1 Peptide - P1296 from Novus Biologicals Category Peptide Species Human

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