Gene Symbol | Acvr2a |
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Entrez Gene | 11480 |
Alt Symbol | ActrIIa, Acvr2, TactrII |
Species | Mouse |
Gene Type | protein-coding |
Description | activin receptor IIA |
Other Description | ACTR-IIA|activin receptor type IIA|activin receptor type-2A |
Swissprots | P27038 |
Accessions | EDL26870 P27038 AK041246 BAC30877 AK050252 BAC34148 AK081022 AK141435 AK143186 AK164527 BC138823 AAI38824 BG066107 BY014959 CK340532 M65287 AAA37171 XM_006497623 XP_006497686 NM_007396 NP_031422 |
Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Brain, testis, intestine, liver and kidney. |
Top Pathways | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells |
ACTR-IIA CRISPR/Cas9 KO Plasmid (m) - sc-418976 from Santa Cruz Biotechnology
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ACTR-IIA HDR Plasmid (m) - sc-418976-HDR from Santa Cruz Biotechnology
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ACTR-IIA Double Nickase Plasmid (m) - sc-418976-NIC from Santa Cruz Biotechnology
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ACTR-IIA Double Nickase Plasmid (m2) - sc-418976-NIC-2 from Santa Cruz Biotechnology
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ACTR-IIA CRISPR Activation Plasmid (m) - sc-418976-ACT from Santa Cruz Biotechnology
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ACTR-IIA CRISPR Activation Plasmid (m2) - sc-418976-ACT-2 from Santa Cruz Biotechnology
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ACTR-IIA Lentiviral Activation Particles (m) - sc-418976-LAC from Santa Cruz Biotechnology
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ACTR-IIA Lentiviral Activation Particles (m2) - sc-418976-LAC-2 from Santa Cruz Biotechnology
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ACTR-IIA siRNA (m) - sc-40207 from Santa Cruz Biotechnology
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ACTR-IIA shRNA Plasmid (m) - sc-40207-SH from Santa Cruz Biotechnology
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ACTR-IIA shRNA (m) Lentiviral Particles - sc-40207-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU079191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26231 from Sigma-Aldrich
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ACVR2A siRNA (Mouse) - CRM0049 from Cohesion Biosciences
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ACVR2A - MBS8202299 from MyBioSource
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ACTR-IIA CRISPR/Cas9 KO Plasmid (m2) - sc-418976-KO-2 from Santa Cruz Biotechnology
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ACTR-IIA HDR Plasmid (m2) - sc-418976-HDR-2 from Santa Cruz Biotechnology
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Mouse ACVR2A siRNA - orb279525 from Biorbyt
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ACVR2A shRNA Plasmid (Mouse) - CHM0049 from Cohesion Biosciences
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