DDB1

Gene Symbol	DDB1
Entrez Gene	1642
Alt Symbol	DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF
Species	Human
Gene Type	protein-coding
Description	damage-specific DNA binding protein 1, 127kDa
Other Description	DDB p127 subunit|DNA damage-binding protein 1|DNA damage-binding protein a|HBV X-associated protein 1|UV-DDB 1|UV-damaged DNA-binding factor|UV-damaged DNA-binding protein 1|XAP-1|XPE-binding factor|xeroderma pigmentosum group E-complementing protein
Swissprots	O15176 Q58F96 B2R648 Q16531 Q13289 B4DG00 A6NG77
Accessions	AAX44048 EAW73933 EAW73934 EAW73935 EAW73936 EAW73937 Q16531 AA665872 AJ002955 CAA05770 AK294341 BAG57611 AK294493 BAH11787 AK299650 BAG61570 AK302924 BAH13845 AK303032 BAG64157 AK311476 AK312436 BAG35345 AL831958 BC011686 AAH11686 BC021044 BC032080 BC050530 AAH50530 BC051764 AAH51764 CD242268 DC334780 L40326 AAA62838 U18299 AAC50349 U32986 AAA88883 NM_001923 NP_001914
Function	Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin- protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate t
Subcellular Location	Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage.
Top Pathways	Ubiquitin mediated proteolysis, Nucleotide excision repair, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DDB1 full length protein - ab114333 from Abcam Category Protein Source Wheat germ Species Human

Human DDB1 peptide - ab23152 from Abcam Category Peptide Species Human

Human DDB1 protein fragment - ab158269 from Abcam Category Protein Source Wheat germ Species Human

DDB1 Antibody Blocking Peptide - LS-E25200 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DDB1 Protein - H00001642-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human DDB1 Protein - H00001642-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DDB1-Antibody-Y660-Blocking-Peptide - BP4780d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DDB1 blocking peptide - GTX89975-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

DDB1 Peptide - AC21-0021-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DDB1 / XAP1 - H00001642-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DDB1 / XAP1 - H00001642-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DDB1 / XAP1 - H00001642-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DDB1 / XAP1 - H00001642-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DDB1 Peptide - 45-048P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

DDB1 fusion protein - Ag17903 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DDB1 fusion protein - ag1901 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DDB1 - DDB1-28308TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human DDB1, His-tagged - DDB1-11877H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DNA damage-binding protein 1(DDB1) ,partial - CSB-YP618079HU CSB-EP618079HU CSB-BP618079HU CSB-MP618079HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DDB1, Peptide - MBS426878 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

DDB1, Peptide - MBS658897 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg

DDB1 Recombinant Protein Antigen - NBP2-38538PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DDB1 Peptide, Human - M34GP04116H from Creative Peptides Category Peptide Source Synthetic. Species Human

DDB1 Recombinant Protein Antigen - NBP2-57877PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DNA damage-binding protein 1 (DDB1), partial, Recombinant Protein - MBS1410752 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more