Cxcl12

Gene Symbol	Cxcl12
Entrez Gene	20315
Alt Symbol	Pbsf, Scyb12, Sdf1, Tlsf, Tpar1
Species	Mouse
Gene Type	protein-coding
Description	chemokine (C-X-C motif) ligand 12
Other Description	12-O-tetradecanoylphorbol 13-acetate repressed protein 1|pre-B-cell growth-stimulating factor|stromal cell-derived factor 1|thymic lymphoma cell-stimulating factor
Swissprots	P40224 Q543V6 Q4FJL5
Accessions	EDK99571 EDK99572 EDK99573 P40224 AK045092 BAC32216 AK075596 BAC35845 AK157553 BAE34120 BB610070 BB840704 BC006640 AAH06640 BC020297 BC029335 BC046827 CT010389 CAJ18596 D21072 BAA04648 D43804 BAA07862 D43805 BAA07863 L12029 AAA40100 L12030 AAA40101 S74318 AAB32650 NM_001012477 NP_001012495 NM_013655 NP_038683 NM_021704 NP_068350
Function	Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-
Subcellular Location	Secreted.
Tissue Specificity	Highest expression levels detected in kidney, liver, spleen and muscle. Isoform Alpha is expressed ubiquitously but at varying levels, while isoform Beta displays tissue-specific expression, with expression detected in kidney, liver, heart, spleen and muscle but not in lung, colon, brain, skin and stomach. {ECO:0000269|PubMed:7982471}.
Top Pathways	Cytokine-cytokine receptor interaction, Axon guidance, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

SDF1 (CXCL12) Mouse ELISA kit - ab100741 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 3 pg/ml Range 9.38 pg/ml - 600 pg/ml

Mouse SDF-1 α / CXCL12 α ELISA Kit - RAB0125 from Sigma-Aldrich Category ELISA Kit Prices $438.50 Sizes 1 kt

SDF-1, Mouse, ELISA Kit - BEK1198 from ARP American Research Products Category ELISA Kit Prices $529.00 Sizes 96 t Sensitivity < 10pg/ml Range 60 pg/ml-4000 pg/ml

SDF-1, Mouse, ELISA Kit - PB-0500 from ARP American Research Products Category ELISA Kit Sensitivity < 10pg/ml Range 62.5pg/ml-4000pg/ml

Stromal Cell Derived Factor 1 (SDF1), Mouse, ELISA Kit - SEA122Mu from ARP American Research Products Category ELISA Kit Prices $668.00 Sizes 96 t Sensitivity 0.059ng/mL Range 0.156-10ng/mL

Stromal cell derived factor 1b, SDF-1b, Mouse, ELISA Kit - CSB-E04723m from ARP American Research Products Category ELISA Kit Prices $465.00, $615.00, $616.00, $619.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Stromal cell-derived factor 1, Cxcl12, Mouse, ELISA Kit - E0477m from ARP American Research Products Category ELISA Kit Prices $496.00 Sizes 96 t Range 0.312-20 ng/mL

Mouse SDF-1 alpha ELISA - ELM-SDF1a from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 3 pg/ml Range 3 pg/ml - 600 pg/ml

Mouse SDF1 ELISA Kit - MS0074 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

SDF-1 ELISA Kit - EK000097-EK0500 from Syd Labs Category ELISA Kit Prices $420.00, $1,428.00 Sizes 1 plate, 96t/plate, 4 plates, 96t/plate Sensitivity < 10pg/ml Range 62.5pg/ml-4000pg/ml

Mouse SDF-1 ELISA Kit - DEIA10870 from Creative Diagnostics Category ELISA Kit Range 62.5 pg/mL-4000 pg/mL

Mouse SDF1 ELISA Kit - DEIA698 from Creative Diagnostics Category ELISA Kit Sensitivity 0.058ng/mL Range 0.156-10ng/mL

Mouse SDF-1 ELISA Kit - DEIA8413 from Creative Diagnostics Category ELISA Kit

Mouse SDF-1/CXCL12(Stromal Cell Derived Factor 1) ELISA Kit - E-EL-M1094 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Mouse SDF1 (Stromal Cell Derived Factor 1) CLIA Kit - E-CL-M0620 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) , ELISA Kit - MBS702526 from MyBioSource Category ELISA Kit Prices $250.00, $450.00, $640.00, $2,615.00, $4,940.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse SDF-1beta is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 pg/ml -2000 pg/ml.

SDF-1, ELISA Kit - MBS355423 from MyBioSource Category ELISA Kit Prices $440.00 Sizes 96 tests Range 62.5 pg/ml-4000 pg/ml

Mouse Stromal cell-derived factor 1 ELISA Kit (2 plates) - BEK-2159-2P from Biosensis Category ELISA Kit Prices $797.00 Sizes 1 kit Sensitivity < 10 pg/ml Range 62.5 pg/ml - 4,000 pg/ml

Mouse Stromal cell derived factor 1β,SDF-1β ELISA kit - CSB-E04723m from Cusabio Category ELISA Kit Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Mouse Stromal Cell Derived Factor 1 ELISA - E03S0067 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for Stromal Cell Derived Factor 1 (SDF1) - SEA122Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 11.7pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA's were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

SDF-1 Mouse ELISA Kit - BEK1198 from Biospes Category ELISA Kit Prices $350.00 Sizes 96 t Range 62.5 pg/ml-4000 pg/ml

Mouse SDF-1/CXCL12(Stromal Cell Derived Factor 1) ELISA Kit - E-EL-M1094 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

Mouse Lptn/XCL1 (Lymphotactin) CLIA Kit - E-CL-M0485 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

Mouse SDF-1 ELISA kit - abx050202 from Abbexa Category ELISA Kit Sensitivity < 10 pg/ml Range 60 pg/ml - 4000 pg/ml

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