| Gene Symbol |
Cxcl12
|
| Entrez Gene |
20315
|
| Alt Symbol |
Pbsf, Scyb12, Sdf1, Tlsf, Tpar1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-X-C motif) ligand 12
|
| Other Description |
12-O-tetradecanoylphorbol 13-acetate repressed protein 1|pre-B-cell growth-stimulating factor|stromal cell-derived factor 1|thymic lymphoma cell-stimulating factor
|
| Swissprots |
P40224 Q543V6 Q4FJL5
|
| Accessions |
EDK99571 EDK99572 EDK99573 P40224 AK045092 BAC32216 AK075596 BAC35845 AK157553 BAE34120 BB610070 BB840704 BC006640 AAH06640 BC020297 BC029335 BC046827 CT010389 CAJ18596 D21072 BAA04648 D43804 BAA07862 D43805 BAA07863 L12029 AAA40100 L12030 AAA40101 S74318 AAB32650 NM_001012477 NP_001012495 NM_013655 NP_038683 NM_021704 NP_068350
|
| Function |
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Highest expression levels detected in kidney, liver, spleen and muscle. Isoform Alpha is expressed ubiquitously but at varying levels, while isoform Beta displays tissue-specific expression, with expression detected in kidney, liver, heart, spleen and muscle but not in lung, colon, brain, skin and stomach. {ECO:0000269|PubMed:7982471}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Axon guidance, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Chemokine signaling pathway
|