CDK2

Gene Symbol	CDK2
Entrez Gene	1017
Alt Symbol	CDKN2, p33(CDK2)
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 2
Other Description	cdc2-related protein kinase|cell division protein kinase 2|p33 protein kinase
Swissprots	O75100 P24941 A8K7C6
Accessions	AAM34794 EAW96856 EAW96857 EAW96858 EAW96859 EAW96860 P24941 AA789250 AA810989 AB012305 BAA32794 AK291941 BAF84630 AK293246 BAG56780 AM393136 CAL38014 BC003065 AAH03065 BJ991087 BT006821 AAP35467 DA814453 DQ890598 ABM92215 DQ893767 ABM84693 M68520 AAA35667 X61622 CAA43807 X62071 CAA43985 XM_011537732 XP_011536034 NM_001290230 NP_001277159 NM_001798 NP_001789 NM_052827 NP_439892
Function	Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).
Top Pathways	Oocyte meiosis, Cell cycle, Measles, Herpes simplex infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® CDK2/CycA Kinase Assay Kit - 7522 from Cell Signaling Technology Category Assay Kit

Cell Cycle Human In-Cell ELISA kit (IR) - ab139412 from Abcam Category ELISA Kit Prices $438.00 Sizes 1 x 96 tests

Cell Cycle In-Cell ELISA Kit (Fluorescent) - ab140363 from Abcam Category ELISA Kit Prices $438.00 Sizes 1 x 96 tests

Human CDK2 ELISA Kit (Sandwich ELISA) - LS-F5061 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.113 ng/ml Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-CDK2 (Thr160) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1068 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat CDK2 ELISA Kit (Cell-Based ELISA) - LS-F1878 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat CDK2 ELISA Kit (Cell-Based ELISA) - LS-F1877 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-CDK2 (Thr14) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1163 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Rat CDK2 ELISA Kit (Sandwich ELISA) - LS-F9029 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.133 ng/ml Range 0.313-20 ng/ml

Mouse CDK2 ELISA Kit (Sandwich ELISA) - LS-F11102 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.313-20 ng/ml

Human CDK2 ELISA Kit (Sandwich ELISA) - LS-F11103 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.313-20 ng/ml

Rabbit anti-CDK2 Antibody, Affinity Purified - PLA0213 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human CDK2 ELISA Kit - abx151013 from Abbexa Category ELISA Kit Sensitivity 0.113 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Cyclin-Dependent Kinase 2 ELISA Kit - abx053446 from Abbexa Category ELISA Kit Sensitivity 0.01 ng/ml Range 0.05 ng/ml - 4 ng/ml

Cyclin Dependent Kinase 2, CDK2, Human, ELISA Kit - E-EL-H2322 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Cyclin Dependent Kinase 2 (CDK2), Human, ELISA Kit - SEB889Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.113ng/mL Range 0.312-20ng/mL

Cyclin-dependent kinase 2 (CDK2), Human, ELISA Kit - CSB-EL005061HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Cyclin-dependent kinase 2, CDK2, Human, ELISA Kit - E1889h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Cyclin Dependent Kinase 2, CDK2, Rabbit, ELISA Kit - E-EL-RB0946 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 2, CDK2, Chicken, ELISA Kit - E-EL-Ch0178 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Cyclin Dependent Kinase 2, CDK2, Porcine, ELISA Kit - E-EL-P1076 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 2, CDK2, Guinea Pig, ELISA Kit - E-EL-GP0082 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin Dependent Kinase 2, CDK2, Monkey, ELISA Kit - E-EL-MK0278 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CDK2 (Human) IP-WB Antibody Pair - H00001017-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human CDK-2 ELISA Kit - HC0729 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

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