| Gene Symbol | Id2 |
|---|---|
| Entrez Gene | 15902 |
| Alt Symbol | AI255428, C78922, Idb2, bHLHb26 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | inhibitor of DNA binding 2 |
| Other Description | DNA-binding protein inhibitor ID-2|inhibitor of differentiation 2 |
| Swissprots | P41136 O88604 |
| Accessions | AAD05214 EDL36979 P41136 AK003222 BAB22651 AK013239 AK013378 AK135547 BAE22577 AK146346 BAE27099 AK146606 BAE27298 BC006921 AAH06921 BC053699 AAH53699 BQ044638 M69293 AAA79771 NM_010496 NP_034626 |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269|PubMed:16556596, ECO:0000269|PubMed:192 |
| Subcellular Location | Cytoplasm. Nucleus. |
| Top Pathways | TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer |