| Gene Symbol |
Slc27a1
|
| Entrez Gene |
94172
|
| Alt Symbol |
FATP
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 27 (fatty acid transporter), member 1
|
| Other Description |
FATP-1|fatty acid transport protein 1|long-chain fatty acid transport protein 1|solute carrier family 27 member 1|solute carrier family 27, member 1
|
| Swissprots |
P97849
|
| Accessions |
EDL90773 EDL90774 EDL90775 EDL90776 P97849 BC074014 AAH74014 U89529 AAC53424 XM_006252953 XP_006253015 XM_006252954 XP_006253016 XM_008771156 XP_008769378 XM_008771157 XP_008769379 NM_053580 NP_446032
|
| Function |
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of Fatp1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15848183}; Single-pass membrane protein {ECO:0000269|PubMed:15848183}. Endomembrane system {ECO:0000269|PubMed:15848183}; Single-pass membrane protein {ECO:0000269|PubMed:15848183}. Cytoplasm {ECO:0000269|PubMed:15848183}. Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes.
|
| Top Pathways |
PPAR signaling pathway
|