ATF4

Gene Symbol	ATF4
Entrez Gene	468
Alt Symbol	CREB-2, CREB2, TAXREB67, TXREB
Species	Human
Gene Type	protein-coding
Description	activating transcription factor 4
Other Description	DNA-binding protein TAXREB67|cAMP response element-binding protein 2|cAMP-dependent transcription factor ATF-4|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-4|cyclic AMP-responsive element-binding protein 2|tax-responsive enhancer element B67|tax-responsive enhancer element-binding protein 67
Swissprots	Q9UH31 P18848
Accessions	EAW60341 EAW60342 P18848 AK057751 AK296028 BAG58796 BC008090 AAH08090 BC011994 AAH11994 BC016855 AAH16855 BC022088 AAH22088 BC024775 AAH24775 BC044895 AAH44895 BC073754 AAH73754 BC073990 AAH73990 CR450353 CAG29349 CR456384 CAG30270 CU012942 CAK54373 CU013230 CAK54672 D90209 BAA14234 DQ891758 ABM82684 DQ894942 ABM85868 M86842 AAA52071 NM_001675 NP_001666 NM_182810 NP_877962
Function	Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000
Subcellular Location	Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome. {ECO:0000250}.
Top Pathways	MAPK signaling pathway, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Adrenergic signaling in cardiomyocytes, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ATF4 ELISA Kit (Sandwich ELISA) - LS-F4324 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Rat ATF4 ELISA Kit (Sandwich ELISA) - LS-F9841 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 28 pg/ml Range 0.156-10 ng/ml

Human ATF4 ELISA Kit - abx150764 from Abbexa Category ELISA Kit Sensitivity 0.057 ng/ml Range 0.156 ng/ml - 10 ng/ml

Activating Transcription Factor 4 (ATF4), Human, ELISA Kit - SEB385Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.057ng/mL Range 0.156-10ng/mL

Activating Transcription Factor 4, Human, ELISA Kit - E01A0534 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/mL Range 0.5-10ng/ml

Activating Transcription Factor 4, ATF4, Human, ELISA Kit - E-EL-H0524 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Cyclic AMP-dependent transcription factor ATF-4 (ATF4), Human, ELISA Kit - E01C1198 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Activating Transcription Factor 4, ATF-4, Rabbit, ELISA Kit - E-EL-RB1025 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Activating Transcription Factor 4, ATF-4, Chicken, ELISA Kit - E-EL-Ch1694 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Activating Transcription Factor 4, ATF-4, Porcine, ELISA Kit - E-EL-P2210 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Activating Transcription Factor 4, ATF-4, Monkey, ELISA Kit - E-EL-MK0453 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

ATF4 (Human) Matched Antibody Pair - H00000468-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human ATF4 ELISA Kit - HA0541 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine ATF4 ELISA Kit - AA0541 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Cyclic AMP dependent transcription factor ATF 4 (ATF4), ELISA Kit - MBS7208446 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ATF4(Activating Transcription Factor 4) ELISA Kit - E-EL-H0524 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Activating Transcription Factor 4, ELISA Kit - MBS037393 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Activating Transcription Factor 4, ELISA Kit - MBS012327 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10pg/ml. Range 62.5pg/ml-2000pg/ml.

Activating Transcription Factor 4, ELISA Kit - MBS054317 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Activating Transcription Factor 4, ELISA Kit - MBS732720 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Activating Transcription Factor 4, ELISA Kit - MBS034364 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Activating Transcription Factor 4, ELISA Kit - MBS021834 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Activating Transcription Factor 4, ELISA Kit - MBS042573 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Activating Transcription Factor 4, ELISA Kit - MBS724320 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Activating Transcription Factor 4, ELISA Kit - MBS726369 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

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