| Gene Symbol |
ATF4
|
| Entrez Gene |
468
|
| Alt Symbol |
CREB-2, CREB2, TAXREB67, TXREB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
activating transcription factor 4
|
| Other Description |
DNA-binding protein TAXREB67|cAMP response element-binding protein 2|cAMP-dependent transcription factor ATF-4|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-4|cyclic AMP-responsive element-binding protein 2|tax-responsive enhancer element B67|tax-responsive enhancer element-binding protein 67
|
| Swissprots |
Q9UH31 P18848
|
| Accessions |
EAW60341 EAW60342 P18848 AK057751 AK296028 BAG58796 BC008090 AAH08090 BC011994 AAH11994 BC016855 AAH16855 BC022088 AAH22088 BC024775 AAH24775 BC044895 AAH44895 BC073754 AAH73754 BC073990 AAH73990 CR450353 CAG29349 CR456384 CAG30270 CU012942 CAK54373 CU013230 CAK54672 D90209 BAA14234 DQ891758 ABM82684 DQ894942 ABM85868 M86842 AAA52071 NM_001675 NP_001666 NM_182810 NP_877962
|
| Function |
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000
|
| Subcellular Location |
Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome. {ECO:0000250}.
|
| Top Pathways |
MAPK signaling pathway, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Adrenergic signaling in cardiomyocytes, Prostate cancer
|
