SCNN1A

Gene Symbol SCNN1A
Entrez Gene 6337
Alt Symbol BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1
Species Human
Gene Type protein-coding
Description sodium channel, non voltage gated 1 alpha subunit
Other Description alpha ENaC-2|alpha-ENaC|alpha-NaCH|amiloride-sensitive epithelial sodium channel alpha subunit|amiloride-sensitive sodium channel subunit alpha|amiloride-sensitive sodium channel subunit alpha 2|epithelial Na(+) channel subunit alpha|nasal epithelial sodium channel alpha subunit|nonvoltage-gated sodium channel 1 subunit alpha|sodium channel, non-voltage-gated 1 alpha subunit|sodium channel, nonvoltage-gated 1 alpha
Swissprots Q6GSQ6 C5HTZ0 A5X2U9 P37088 B4E2Q5 Q9UM64 O43271
Accessions AAA21813 AAC31773 AAC31774 AAD28355 ACS13719 ACS13720 ACS13721 ACS13722 CAB07505 EAW88803 EAW88804 P37088 AK025536 AK172792 AK304379 BAG65217 AY365119 AAQ67341 BC006526 AAH06526 BC037417 BC062613 AAH62613 BU680600 DB232484 DQ402522 ABD72218 X76180 CAA53773 NM_001038 NP_001029 NM_001159575 NP_001153047 NM_001159576 NP_001153048
Function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:24124190}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:22207244}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium {ECO:0000269|PubMed:22207244}. Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non- ciliated epithelial cells, restricted to apical surfaces. {ECO:0000269|PubMed:22207244, ECO:0000269|PubMed:24124190}.
Tissue Specificity Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. {ECO:0000269|PubMed:22207244, ECO:0000269|PubMed:9575806}.
Top Pathways Taste transduction, Aldosterone-regulated sodium reabsorption

αENaC (H-95) - sc-21012 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
αENaC (H-95): sc-21012. Western blot analysis of human recombinant αENaC fusion protein.

αENaC (C-20) - sc-22239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
αENaC (C-20): sc-22239. Western blot analysis of αENaC expression in KNRK (A), HeLa (B) and NIH/3T3 (C) whole cell lysates.

αENaC (N-20) - sc-22237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-epithelial Sodium Channel alpha antibody - ab65710 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab65710 stained HeLa cells. The cells were 4% formaldehyde (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab65710, 1/200 dilution) overnight at +4°C. The secondary antibody (green) was ab96899 Dylight 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-epithelial Sodium Channel alpha antibody - ab74838 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-epithelial Sodium Channel alpha antibody - ab81091 from Abcam

Host Sheep
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (aa182-459) IHC-plus™ - LS-B10784 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SCNN1A / ENaC Apha antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10784 concentration 7.5 ug/ml.

Anti-SCNN1A / ENaC Alpha Antibody - LS-C334121 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Mouse brain , using SCNN1A antibody.

Anti-SCNN1A / ENaC Alpha Antibody (aa365-391) - LS-C162900 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma reacted with SCNN1A Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-SCNN1A / ENaC Alpha Antibody (N-Terminus) - LS-C23187 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (N-Terminus) - LS-C23186 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (N-Terminus) - LS-C124570 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (Extracellular Domain) - LS-C136396 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (APC) - LS-C226392 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (Biotin) - LS-C226393 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (AP) - LS-C226391 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (Azide-free, HRP) - LS-C226395 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (FITC) - LS-C226394 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (PE) - LS-C226396 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (aa46-68, Atto 390) - LS-C229765 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (aa46-68, Atto 488) - LS-C229766 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (aa46-68, Atto 565) - LS-C229767 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (aa46-68, Atto 594) - LS-C230310 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody (aa46-68, Atto 633) - LS-C230312 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1A / ENaC Alpha Antibody - LS-C150448 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of ENaC-Alpha in rat kidney tissue using a 1:1000 dilution of SCNN1A / ENaC Apha antibody.
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