SCNN1A

Gene Symbol	SCNN1A
Entrez Gene	6337
Alt Symbol	BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1
Species	Human
Gene Type	protein-coding
Description	sodium channel, non voltage gated 1 alpha subunit
Other Description	alpha ENaC-2|alpha-ENaC|alpha-NaCH|amiloride-sensitive epithelial sodium channel alpha subunit|amiloride-sensitive sodium channel subunit alpha|amiloride-sensitive sodium channel subunit alpha 2|epithelial Na(+) channel subunit alpha|nasal epithelial sodium channel alpha subunit|nonvoltage-gated sodium channel 1 subunit alpha|sodium channel, non-voltage-gated 1 alpha subunit|sodium channel, nonvoltage-gated 1 alpha
Swissprots	Q6GSQ6 C5HTZ0 A5X2U9 P37088 B4E2Q5 Q9UM64 O43271
Accessions	AAA21813 AAC31773 AAC31774 AAD28355 ACS13719 ACS13720 ACS13721 ACS13722 CAB07505 EAW88803 EAW88804 P37088 AK025536 AK172792 AK304379 BAG65217 AY365119 AAQ67341 BC006526 AAH06526 BC037417 BC062613 AAH62613 BU680600 DB232484 DQ402522 ABD72218 X76180 CAA53773 NM_001038 NP_001029 NM_001159575 NP_001153047 NM_001159576 NP_001153048
Function	Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:24124190}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:22207244}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium {ECO:0000269|PubMed:22207244}. Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non- ciliated epithelial cells, restricted to apical surfaces. {ECO:0000269|PubMed:22207244, ECO:0000269|PubMed:24124190}.
Tissue Specificity	Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. {ECO:0000269|PubMed:22207244, ECO:0000269|PubMed:9575806}.
Top Pathways	Taste transduction, Aldosterone-regulated sodium reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SCNN1A / ENaC Alpha ELISA Kit (Sandwich ELISA) - LS-F8070 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Rat SCNN1A / ENaC Alpha ELISA Kit (Sandwich ELISA) - LS-F8625 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a), Human, ELISA Kit - SED337Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.067ng/mL Range 0.156-10ng/mL

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), Human, ELISA Kit - E01A1964 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a), ELISA Kit - MBS9308936 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride sensitive sodium channel subunit Alpha (SCNN1A), ELISA Kit - MBS7239899 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha, ELISA Kit - MBS282580 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha, ELISA Kit - MBS280575 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7237132 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7209744 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7209765 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7204661 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7223693 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7243463 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7225295 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml.

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7218398 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7212517 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7216358 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Amiloride-sensitive sodium channel subunit alpha (SCNN1A), ELISA Kit - MBS7244537 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

sodium channel, nonvoltage-gated 1 alpha, ELISA Kit - MBS9331347 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) - SED337Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.060ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) - SED337Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) - SED337Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.060ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human SCNN1a ELISA Kit - abx153031 from Abbexa Category ELISA Kit Sensitivity 0.060 ng/ml Range 0.156 ng/ml - 10 ng/ml

Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a), Human, ELISA Kit - DL-SCNN1a-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

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