CDH2

Gene Symbol CDH2
Entrez Gene 1000
Alt Symbol CD325, CDHN, CDw325, NCAD
Species Human
Gene Type protein-coding
Description cadherin 2, type 1, N-cadherin (neuronal)
Other Description N-cadherin 1|cadherin 2, N-cadherin (neuronal)|cadherin-2|calcium-dependent adhesion protein, neuronal|neural cadherin|neural-cadherin
Swissprots Q14923 Q8N173 B0YIY6 A8MWK3 P19022
Accessions ACA05964 CAA81799 CCD32808 CCE25962 EAX01239 EAX01240 EAX01241 P19022 AA661623 AI675151 AI752179 AI752180 AK302831 BAH13814 AW016710 BC021695 BC036470 AAH36470 BG197310 BX648579 CB105441 CN263272 DA225616 DC403359 EU832318 ACE87575 EU832403 ACE86888 M34064 AAA03236 S42303 AAB22854 X54315 CAA38213 X57548 CAA40773 XM_005258181 XP_005258238 XM_005258182 XP_005258239 XM_011525787 XP_011524089 XM_011525788 XP_011524090 NM_001308176 NP_001295105 NM_001792 NP_001783
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Top Pathways Cell adhesion molecules (CAMs), Arrhythmogenic right ventricular cardiomyopathy (ARVC)

N-Cadherin (D4R1H) XP ® Rabbit mAb - 13116 from Cell Signaling Technology

Prices $109.00, $282.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4R1H
Western blot analysis of extracts from A172 and MCF7 cells using N-Cadherin (D4R1H) XP ® Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

N-Cadherin (13A9) Mouse mAb - 14215 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 13A9
Western blot analysis of PANC-1 cells (positive) and MCF7 cells (negative) using N-Cadherin (13A9) Mouse mAb (upper) or α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower).

N-Cadherin Antibody - 4061 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A431, MCF-7, C2C12, HUVEC, BAEC, C6 and H-4-II-E cells, using N-cadherin Antibody.

N-cadherin (H-2) - sc-393933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
N-cadherin (H-2): sc-393933. Western blot analysis of N-cadherin expression in mouse brain (A) and human heart (B) tissue extracts.

N-cadherin (H-4) - sc-271386 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
N-cadherin (H-4): sc-271386. Western blot analysis of N-cadherin expression in PC-12 whole cell lysate.

N-cadherin (H-63) - sc-7939 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
N-cadherin (H-63): sc-7939. Western blot analysis of N-cadherin expression in PC-12 whole cell lysate.

N-cadherin (K-20) - sc-31030 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-cadherin (K-20): sc-31030. Western blot analysis of N-cadherin expression in non-transfected: sc-117752 (A) and mouse N-cadherin transfected: sc-121905 (B) 293T whole cell lysates.

N-cadherin (N-19) - sc-1502 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-cadherin (N-19): sc-1502. Western blot analysis of N-cadherin expression in A-10 whole cell lysate.

N-cadherin (C-16) - sc-31031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-cadherin (C-16): sc-31031. Western blot analysis of N-cadherin expression in mouse brain tissue extract.

N-cadherin (D-4) - sc-8424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
N-cadherin (D-4): sc-8424. Western blot analysis of human recombinant N-cadherin fusion protein.

N-cadherin (L-13) - sc-31029 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-cadherin (L-13): sc-31029. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing membrane and cytoplasmic staining of myocytes.

N-cadherin (13A9) - sc-59987 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
N-cadherin (13A9): sc-59987. Western blot analysis of N-cadherin expression in human cerebral cortex (A) and human heart (B) tissue extracts.

N-cadherin (8C11) - sc-53488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
N-cadherin (8C11): sc-53488. Western blot analysis of N-cadherin expression in human cerebral cortex (A) and human heart (B) tissue extracts.

Anti-N Cadherin (phospho Y820) antibody - ab76059 from Abcam

Prices $380.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-N Cadherin (phospho Y820) antibody (ab76059) at 1/1000 dilutionLane 1 : Human endothelial cells untreatedLane 2 : Human endothelial cells treated with pervanadate (1 mM) for 30 minLane 3 : Human endothelial cells treated with pervanadate (1 mM) for 30 min with phospho-N-cadherin (Tyr-820) peptideLane 4 : Human endothelial cells treated with pervanadate (1 mM) for 30 min with phospho-N-cadherin (Tyr-860) peptide

Anti-N Cadherin (phospho Y860) antibody - ab119752 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab119752 at 1/200 dilution staining N Cadherin (phospho Y860) in Mouse C2C12 cells, treated with pervanadate (right). The cells on the left were not treated with pervanadate prior to analysis. Detection used an appropriate secondary antibody conjugated to Cy3.

Anti-N Cadherin antibody - ab95440 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-N Cadherin antibody (ab95440) at 1 µg/mlLane 1 : Rat liver tissue lysateLane 2 : Rat liver tissue lysateLane 3 : Rat brain tissue lysateLane 4 : Rat testicular tissue lysateLysates/proteins at 100 µg per lane.

Anti-N Cadherin antibody [2G7] - ab124397 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G7
All lanes : Anti-N Cadherin antibody [2G7] (ab124397) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY N CadherinLysates/proteins at 5 µg per lane.

Anti-N Cadherin antibody [5D5] - ab98952 from Abcam

Prices $398.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D5
All lanes : Anti-N Cadherin antibody [5D5] (ab98952) at 1/500 dilutionLane 1 : A431 cell lysateLane 2 : NIH-3T3 cell lysateLane 3 : HeLa cell lysateLane 4 : C6 cell lysateLane 5 : LNCap cell lysate

Anti-N Cadherin antibody [8C11] - ab19348 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8C11
Lane 1 : Anti-N Cadherin antibody [8C11] (ab19348) at 1/1000 dilutionLanes 2 - 3 : Anti-N Cadherin antibody [8C11] (ab19348) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : HUVEC cell lysateLane 3 : C2C12 cell lysateLysates/proteins at 25 µg per lane.Observed band size : 140 kDa (why is the actual band size different from the predicted?)

Anti-N Cadherin antibody [8C11] (Biotin) - ab93524 from Abcam

Prices $189.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 8C11
Flow Cytometry staining of Hela cell line with Biotin Mouse IgG1, K Isotype Control (blue histogram) or ab93524 (purple histogram) followed by Streptavidin PE. Total viable cells were used for analysis.

Anti-N Cadherin antibody [8C11] (Phycoerythrin) - ab93525 from Abcam

Prices $189.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 8C11
Staining of HeLa cells with PE Mouse IgG1 kappa Isotype Control (blue histogram), or ab93525. Total viable cells were used for analysis.

Anti-N Cadherin antibody [EPR1791-4] - ab76011 from Abcam

Prices $398.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1791-4
ab76011 staining N Cadherin in Mouse pancreas tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 1% BSA + 1% FBS for 2 hours at room temperature; antigen retrieval was by heat mediation in a citrate buffer pH6. Samples were incubated with primary antibody (1/500 in 1% BSA + 1% FBS) for 16 hours at 4°C. An undiluted HRP-conjugated Goat anti-rabbit IgG polyclonal was used as the secondary antibody.See Abreview

Anti-N Cadherin antibody [EPR1791-4] (Alexa Fluor® 647) - ab195186 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1791-4
Overlay histogram showing SH-SY5Y cells stained with ab195186 (red line). The cells were fixed with 80% methanol (5 min). The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab195186, 1/50 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 647 used at the same concentration and conditions as the primary antibody.Unlabelled sample (blue line) was also used as a control.Acquisition of >5,000 events were collected using a solid-state 25mW red diode laser (635 nm) and 675/30 bandpass filter.

Anti-N Cadherin antibody [EPR1791-4] (HRP) - ab195187 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1791-4
IHC image of N Cadherin staining in a section of formalin-fixed paraffin-embedded normal human cerebellum, performed on a Leica BOND. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20mins. The section was then incubated with ab195187 at 1/70 dilution, for 15 mins at room temperature. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset negative control image is taken from an identical assay without primary antibody.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-N Cadherin antibody, prediluted - ab82140 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab82140, prediluted, staining Cadherin in formalin fixed, paraffin embedded, human pituitary by Immunohistochemistry.
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