COL4A3

Gene Symbol COL4A3
Entrez Gene 1285
Alt Symbol -
Species Human
Gene Type protein-coding
Description collagen, type IV, alpha 3 (Goodpasture antigen)
Other Description collagen IV, alpha-3 polypeptide|collagen alpha-3(IV) chain|tumstatin
Swissprots Q9UDJ9 Q01955 Q53RW8 Q9UDL0 Q9UDK9 Q9NYC4 Q53QQ1 Q53R14 Q9BQT2 Q9UDL1
Accessions AAA52044 AAF63713 AAX93111 AAY14671 AAY24251 BAA25064 CAC36101 EAW70848 EAW70849 EAW70850 EAW70851 EAW70852 EAW70853 EAW70854 EAW70855 EAW70856 EAW70857 Q01955 AF258351 AAF72632 AU099354 BC156138 AAI56139 BM670570 BM712932 CD675393 EU268882 ABX71213 M81379 AAA51556 M92993 AAA21610 S55790 AAB19637 U02519 AAA18942 U02520 AAA18943 X80031 CAA56335 XM_005246276 XP_005246333 XM_005246277 XP_005246334 XM_005246280 XP_005246337 XM_006712245 XP_006712308 XM_011510555 XP_011508857 XM_011510556 XP_011508858 XR_241280 NM_000091 NP_000082 NM_031362 NM_031363 NM_031364 NM_031365 NM_031366
Function Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}.
Tissue Specificity Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. According to PubMed:8083201, alpha 3 type IV collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial and perineurial nerves, fetal brain, fetal heart and fetal liver. According to PubMed:7523402, alpha 3 type IV collagen is strongly expressed in pancreas, neuroretina and calvaria and not expressed in adrenal, ileum and skin. Isoform 1 and isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle and spleen, in each of these tissues isoform 1 is more abundant than isoform 3.
Top Pathways Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Protein digestion and absorption

COL4A3 CRISPR/Cas9 KO Plasmid (h) - sc-400903 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A3 HDR Plasmid (h) - sc-400903-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A3 Double Nickase Plasmid (h) - sc-400903-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A3 Double Nickase Plasmid (h2) - sc-400903-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A3 CRISPR Activation Plasmid (h) - sc-400903-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A3 CRISPR Activation Plasmid (h2) - sc-400903-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A3 Lentiviral Activation Particles (h) - sc-400903-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A3 Lentiviral Activation Particles (h2) - sc-400903-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COL4A3 siRNA (h) - sc-105228 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COL4A3 shRNA Plasmid (h) - sc-105228-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COL4A3 shRNA (h) Lentiviral Particles - sc-105228-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU095961 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6391 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6391 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

COL4A3 siRNA (Human) - CRH0899 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COL4A3 - MBS8219400 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COL4A3 (NM_000091.4) - SHH267285 from Creative biogene

Category siRNA
Species Reactivities Human

Human Collagen IV siRNA - orb261401 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COL4A3 shRNA Plasmid (Human) - CHH0899 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COL4A3 miRNA 3'UTR clone - MiUTR4H-TG10939 from Creative biogene

Species Reactivities Human
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