ACIN1

Gene Symbol	ACIN1
Entrez Gene	22985
Alt Symbol	ACINUS, ACN, fSAP152
Species	Human
Gene Type	protein-coding
Description	apoptotic chromatin condensation inducer 1
Other Description	apoptotic chromatin condensation inducer in the nucleus|functional spliceosome-associated protein 152
Swissprots	Q9UKV3 Q9UG91 Q9UKV2 O75158 D3DS45 B2RTT4 Q9UKV1
Accessions	EAW66186 EAW66187 EAW66188 Q9UKV3 AB014570 BAA31645 AF124726 AAD56724 AF124727 AAD56725 AF124728 AAD56726 AK299034 BAG61109 AL050382 CAB43681 AL833228 CAH10608 BC032770 BC140805 AAI40806 BX247975 CAD62309 CX786860 XM_005267415 XP_005267472 XM_005267416 XP_005267473 XM_005267418 XP_005267475 XM_006720081 XP_006720144 XM_011536569 XP_011534871 XM_011536570 XP_011534872 XR_429297 NM_001164814 NP_001158286 NM_001164815 NP_001158287 NM_001164816 NP_001158288 NM_001164817 NP_001158289 NM_014977 NP_055792
Function	Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence- independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different f
Subcellular Location	Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
Tissue Specificity	Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
Top Pathways	Spliceosome, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Acinus Antibody - 4934 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Acinus (K-14) - sc-5430 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Acinus (V-16) - sc-5432 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AcinusL (N-17) - sc-5433 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AcinusL (N-18) - sc-5434 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AcinusS (N-10) - sc-5435 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Acinus (2005C3a) - sc-81177 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-Acinus antibody - ab7352 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Acinus antibody - ab7353 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Acinus antibody - ab7354 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Acinus antibody - ab84454 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Acinus antibody - ab55938 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Acinus antibody - ab7355 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Acinus antibody - ab18519 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Acinus antibody - ab125318 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Acinus antibody [2005C3a] - ab50827 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2005C3a

Anti-ACIN1 / Acinus Antibody - LS-C11730 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ACIN1 / Acinus Antibody (aa1271-1284) - LS-C2594 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ACIN1 / Acinus Antibody (C-Terminus) - LS-C11737 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ACIN1 / Acinus Antibody (aa994-1009) - LS-C373 from LifeSpan Bioscience Prices $325.00, $890.00 Sizes 100 µg, 500 µg Host Rabbit Clonality Polyclonal

Anti-ACIN1 / Acinus Antibody (aa1233-1341) - LS-C11740 from LifeSpan Bioscience Prices $575.00 Sizes 200 µg Host Rabbit Clonality Polyclonal

Anti-ACIN1 / Acinus Antibody (aa1-108) - LS-C11741 from LifeSpan Bioscience Prices $545.00 Sizes 200 µg Host Rabbit Clonality Polyclonal

Anti-ACIN1 / Acinus Antibody (C-Terminus) - LS-C328 from LifeSpan Bioscience Prices $345.00, $1,035.00 Sizes 100 µg, 500 µg Host Rabbit Clonality Polyclonal

Anti-ACIN1 / Acinus Antibody - LS-C26595 from LifeSpan Bioscience Prices $360.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ACIN1 / Acinus Antibody - LS-C26596 from LifeSpan Bioscience Prices $360.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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