ACIN1

Gene Symbol	ACIN1
Entrez Gene	22985
Alt Symbol	ACINUS, ACN, fSAP152
Species	Human
Gene Type	protein-coding
Description	apoptotic chromatin condensation inducer 1
Other Description	apoptotic chromatin condensation inducer in the nucleus|functional spliceosome-associated protein 152
Swissprots	Q9UKV3 Q9UG91 Q9UKV2 O75158 D3DS45 B2RTT4 Q9UKV1
Accessions	EAW66186 EAW66187 EAW66188 Q9UKV3 AB014570 BAA31645 AF124726 AAD56724 AF124727 AAD56725 AF124728 AAD56726 AK299034 BAG61109 AL050382 CAB43681 AL833228 CAH10608 BC032770 BC140805 AAI40806 BX247975 CAD62309 CX786860 XM_005267415 XP_005267472 XM_005267416 XP_005267473 XM_005267418 XP_005267475 XM_006720081 XP_006720144 XM_011536569 XP_011534871 XM_011536570 XP_011534872 XR_429297 NM_001164814 NP_001158286 NM_001164815 NP_001158287 NM_001164816 NP_001158288 NM_001164817 NP_001158289 NM_014977 NP_055792
Function	Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence- independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different f
Subcellular Location	Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
Tissue Specificity	Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
Top Pathways	Spliceosome, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Acinus peptide - ab8367 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Acinus peptide - ab8368 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Acinus peptide - ab8369 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Acinus peptide - ab8370 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human Acinus protein fragment - ab153201 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ACIN1 / Acinus Antibody Blocking Peptide - LS-E21314 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACIN1 / Acinus Antibody Blocking Peptide - LS-E29914 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ACIN1 / Acinus Antibody Blocking Peptide - LS-E29915 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ACIN1 / Acinus Antibody Blocking Peptide - LS-E29916 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ACIN1 / Acinus Antibody Blocking Peptide - LS-E29925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Acinus Partial Recombinant Protein - H00022985-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Acinus Peptide - NBP1-76459PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Acinus Blocking Peptide - NBP1-76855PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Acinus Blocking Peptide - NBP1-76856PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Acinus Blocking Peptide - NBP1-76869PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Acinus peptide - GTX28367 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Acinus peptide - GTX28368 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Acinus peptide - GTX28369 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Acinus peptide - GTX28370 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Acinus / ACIN1 - H00022985-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Acinus / ACIN1 - H00022985-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Acinus / ACIN1 Control Peptide - AP30010CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Acinus / ACIN1 Control Peptide - AP30011CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Acinus / ACIN1 Control Peptide - AP30012CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Acinus / ACIN1 Control Peptide - AP30013CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Search more