TGFB1
| Gene Symbol | TGFB1 |
|---|---|
| Entrez Gene | 7040 |
| Alt Symbol | CED, DPD1, LAP, TGFB, TGFbeta |
| Species | Human |
| Gene Type | protein-coding |
| Description | transforming growth factor, beta 1 |
| Other Description | TGF-beta-1|latency-associated peptide|prepro-transforming growth factor beta-1|transforming growth factor beta-1 |
| Swissprots | Q9UCG4 P01137 A8K792 |
| Accessions | AAL27646 AAN86616 AAQ18641 AAQ18642 AAT77143 AAT77144 AAX59016 AAX59017 AAX59018 AAX59019 AAX59020 AAX59021 AAX59022 AAX59023 AAX59024 AAX59025 AAX59026 AAX59027 AAX59028 AAX59029 ACA64647 ACA64648 ACA64649 CAA29283 CAF32686 CAP12291 CAP40172 CBN73463 CBN73468 CCA63970 CDW91956 CDW91957 CDW91958 CDW91959 CDW91960 CDW91961 CDW91962 CDW91963 CDW91964 CDW91965 CDW91966 CDW91967 CDW91968 CDW91969 CDW91970 CDW91971 CDW91972 CDW91973 CDW91974 EAW57032 EAW57033 P01137 AI304490 AK291907 BAF84596 AK307742 AY820829 AAV71148 BC000125 AAH00125 BC001180 AAH01180 BC022242 AAH22242 BG115704 BP267938 BT007245 AAP35909 DA935180 EU832132 ACE87482 EU832225 ACE86795 M38449 AAA36735 X02812 CAA26580 XM_011527242 XP_011525544 NM_000660 NP_000651 |
| Function | Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. {ECO:0000250|UniProtKB:P04202}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}. |
| Tissue Specificity | Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage. {ECO:0000269|PubMed:11746498, ECO:0000269|PubMed:17827158}. |
| Top Pathways | Hippo signaling pathway, Rheumatoid arthritis, HTLV-I infection, Tuberculosis, Proteoglycans in cancer |
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