TGFB1

Gene Symbol TGFB1
Entrez Gene 7040
Alt Symbol CED, DPD1, LAP, TGFB, TGFbeta
Species Human
Gene Type protein-coding
Description transforming growth factor, beta 1
Other Description TGF-beta-1|latency-associated peptide|prepro-transforming growth factor beta-1|transforming growth factor beta-1
Swissprots Q9UCG4 P01137 A8K792
Accessions AAL27646 AAN86616 AAQ18641 AAQ18642 AAT77143 AAT77144 AAX59016 AAX59017 AAX59018 AAX59019 AAX59020 AAX59021 AAX59022 AAX59023 AAX59024 AAX59025 AAX59026 AAX59027 AAX59028 AAX59029 ACA64647 ACA64648 ACA64649 CAA29283 CAF32686 CAP12291 CAP40172 CBN73463 CBN73468 CCA63970 CDW91956 CDW91957 CDW91958 CDW91959 CDW91960 CDW91961 CDW91962 CDW91963 CDW91964 CDW91965 CDW91966 CDW91967 CDW91968 CDW91969 CDW91970 CDW91971 CDW91972 CDW91973 CDW91974 EAW57032 EAW57033 P01137 AI304490 AK291907 BAF84596 AK307742 AY820829 AAV71148 BC000125 AAH00125 BC001180 AAH01180 BC022242 AAH22242 BG115704 BP267938 BT007245 AAP35909 DA935180 EU832132 ACE87482 EU832225 ACE86795 M38449 AAA36735 X02812 CAA26580 XM_011527242 XP_011525544 NM_000660 NP_000651
Function Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. {ECO:0000250|UniProtKB:P04202}.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}.
Tissue Specificity Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage. {ECO:0000269|PubMed:11746498, ECO:0000269|PubMed:17827158}.
Top Pathways Hippo signaling pathway, Rheumatoid arthritis, HTLV-I infection, Tuberculosis, Proteoglycans in cancer

TGF-β (56E4) Rabbit mAb - 3709 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 56E4
Western blot analysis of recombinant active TGF-β1 using TGF-β (56E4) Rabbit mAb.

TGF-β Antibody - 3711 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HCT 116, A20, and NBT-II cells using TGF-beta Antibody.

LAP (T-17) - sc-34830 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LAP (J-17A) - sc-80151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
LAP (J-17A): sc-80151. Western blot analysis of LAP expression in Caki-1 whole cell lysate.

TGFβ (hTGF-β) - sc-73337 from Santa Cruz Biotechnology

Host Mouse
Clonality Monoclonal

TGF β1 (3C11) - sc-130348 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TGF β1 (3C11): sc-130348. Western blot analysis of human recombinant TGF β1.

TGFβ1 (V) - sc-146 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TGFβ1 (V): sc-146. Immunoperoxidase staining of formalin fixed, paraffin-embedded porcine uterus tissue. Kindly provided by Laurie A. Jaeger.

TGFβ1 (D-12) - sc-31608 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TGFβ1 (C-16) - sc-31609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TGFβ1 (2E6) - sc-52892 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TGFβ1 (2E6): sc-52892. Western blot analysis of TGFβ1 expression in platelet extract.

TGFβ1 (500-M66) - sc-65378 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TGFβ1 (500-M66): sc-65378. Western blot analysis of TGFβ1 expression in platelet extract.

TGFβ1 (TB21) - sc-52893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TGFβ1 (TB21): sc-52893. Western blot analysis of TGFβ1 expression in platelet extract.

TGFβ3 (G-9) - sc-166833 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TGFβ3 (G-9): sc-166833. Western blot analysis of human recombinant TGFβ3 fusion protein.

TGFβ1/2/3 (H-112) - sc-7892 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TGFβ1/2/3 (H-112): sc-7892. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing cytoplasmic staining of glandular cells.

Anti-TGF beta 1 + 2 antibody [EPR5443] - ab124894 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5443
All lanes : Anti-TGF beta 1 + 2 antibody [EPR5443] (ab124894) at 1/1000 dilutionLane 1 : A549 lysateLane 2 : K562 lysateLane 3 : L929 lysateLysates/proteins at 10 µg per lane.

Anti-TGF beta 1 antibody - ab92486 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-TGF beta 1 antibody (ab92486) at 0.5 µg/ml + RAW264.7 cell lysate 20-40 ug

Anti-TGF beta 1 antibody - ab9758 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis using ab9758 at 1/200 to detect human TGFß1. Each lane contains 250 ng of protein under non-reducing (lane 1) and reducing conditions (lane 2). Comparison to molecular weight markers (not shown) was used to estimate the indicated molecular weights. TGF beta 1 is a 25kD homodimer composed of two 12.5kD subunits joined by disulfide bonds. Therefor a 25kD band is seen in the non-reducing lane and a 12kD band in the reducing lane.

Anti-TGF beta 1 antibody - ab46780 from Abcam

Prices $378.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
ICC/IF image of ab46780 stained T24/83 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab46780 at 1µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- chicken (ab150173) IgY (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-TGF beta 1 antibody - ab155264 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TGF beta 1 antibody (ab155264) at 1/1000 dilutionLane 1 : Raji whole cell lysateLane 2 : K562 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-TGF beta 1 antibody - ab125287 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab125287, at 1/25 dilution, staining TGF beta 1 in formalin-fixed, paraffin-embedded Human placenta tissue by Immunohistochemistry.

Anti-TGF beta 1 antibody - ab27937 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TGF beta 1 antibody - ab10518 from Abcam

Prices $370.00
Sizes 25 µg
Host Chicken
Clonality Polyclonal

Anti-TGF beta 1 antibody - ab74525 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab74525 at 1/25 dilution staining TGF beta 1 in human placenta by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

Anti-TGF beta 1 antibody - ab30838 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TGF beta 1 antibody [2Ar2] - ab64715 from Abcam

Host Mouse
Clonality Monoclonal
Clone 2Ar2
Immunohistochemical staining of immersion fixed, paraffin-embedded secton of human prostate cancer tissue using ab64715 at 25ug/ml with overnight incubation at 4°C. Tissue was stained using HRP-DAB detection sytem and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of epithelial cells in the prostate gland.
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