| Gene Symbol |
Pdcd1lg2
|
| Entrez Gene |
58205
|
| Alt Symbol |
B7-DC, Btdc, F730015O22Rik, PD-L2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
programmed cell death 1 ligand 2
|
| Other Description |
PD-1 ligand 2|PDCD1 ligand 2|butyrophilin B7-DC|butyrophilin-like protein|programmed death ligand 2
|
| Swissprots |
Q9WUL5
|
| Accessions |
EDL41682 EDL41683 Q9WUL5 AF142780 AAD33892 AK041369 AK089369 BAC40858 AK141111 BAE24564 AK155002 BAE32986 BC104138 AAI04139 BC104139 AAI04140 BY749628 XM_011247309 XP_011245611 NM_021396 NP_067371
|
| Function |
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. {ECO:0000269|PubMed:11224527, ECO:0000269|PubMed:11283156, ECO:0000269|PubMed:12719480}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in immature and mature bone marrow- derived dendritic cells and splenic dendritic cells. Highly expressed in placenta, liver and weakly expressed in heart, spleen, lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin. {ECO:0000269|PubMed:11224527, ECO:0000269|PubMed:11283156}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|