CFL1

Gene Symbol	CFL1
Entrez Gene	1072
Alt Symbol	CFL, HEL-S-15
Species	Human
Gene Type	protein-coding
Description	cofilin 1 (non-muscle)
Other Description	18 kDa phosphoprotein|cofilin, non-muscle isoform|cofilin-1|epididymis secretory protein Li 15|p18
Swissprots	P23528 Q9UCA2 Q53Y87 B3KUQ1
Accessions	EAW74448 EAW74449 EAW74450 EAW74451 EAW74452 P23528 AK097690 BAG53513 AK303614 BAG64624 BC011005 AAH11005 BC012265 AAH12265 BC012318 AAH12318 BC018256 AAH18256 BC024975 BT006846 AAP35492 CB850882 D00682 BAA00589 D28345 BAA05711 DQ891769 ABM82695 EU176624 ABW03425 EU794603 ACJ13657 HM370399 U21909 AAA64501 X95404 CAA64685 NM_005507 NP_005498
Function	Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. {ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}.
Subcellular Location	Nucleus matrix {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Tissue Specificity	Widely distributed in various tissues.
Top Pathways	Axon guidance, Fc gamma R-mediated phagocytosis, Pertussis, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cofilin full length protein - ab95396 from Abcam Category Protein Source E. coli Species Human

Human Cofilin full length protein - ab62958 from Abcam Category Protein Source E. coli Species Human

Human Cofilin full length protein - ab85154 from Abcam Category Protein Source E. coli Species Human

Human Cofilin full length protein - ab87958 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

Human Cofilin peptide - ab37634 from Abcam Category Peptide Species Human

Human Cofilin peptide - ab42822 from Abcam Category Peptide

Human Cofilin peptide - ab42823 from Abcam Category Peptide

CFL1-Antibody-Center-Blocking-Peptide - BP2905c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CFL1-Antibody-N-term-Blocking-Peptide - BP2905a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-CofilinSer3-Antibody-Blocking-peptide - BP3751a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

CFL1 Protein (OPPA01581) - OPPA01581 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Cofilin 1 protein (His tag) - 80R-1034 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

Human CFL1 Protein - abx060026 from Abbexa Category Protein Source Yeast Species Human

Human Cofilin 1, Non Muscle Protein - abx065989 from Abbexa Category Protein Source E.coli Species Human

Cofilin-1 (1-166, His-tag) - AR09012PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

Cofilin-1 (1-166, His-tag) - AR09012PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

Cofilin-1 - H00001072-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cofilin-1 - H00001072-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Cofilin-1 - H00001072-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Cofilin-1 - H00001072-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cofilin-1 - H00001072-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cofilin-1, Human Recombinant - 228-10220-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human CFL1 - 228-10220-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human CFL1 - 228-10220-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

Cofilin fusion protein - Ag1399 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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