CFL1

Gene Symbol	CFL1
Entrez Gene	1072
Alt Symbol	CFL, HEL-S-15
Species	Human
Gene Type	protein-coding
Description	cofilin 1 (non-muscle)
Other Description	18 kDa phosphoprotein|cofilin, non-muscle isoform|cofilin-1|epididymis secretory protein Li 15|p18
Swissprots	P23528 Q9UCA2 Q53Y87 B3KUQ1
Accessions	EAW74448 EAW74449 EAW74450 EAW74451 EAW74452 P23528 AK097690 BAG53513 AK303614 BAG64624 BC011005 AAH11005 BC012265 AAH12265 BC012318 AAH12318 BC018256 AAH18256 BC024975 BT006846 AAP35492 CB850882 D00682 BAA00589 D28345 BAA05711 DQ891769 ABM82695 EU176624 ABW03425 EU794603 ACJ13657 HM370399 U21909 AAA64501 X95404 CAA64685 NM_005507 NP_005498
Function	Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. {ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}.
Subcellular Location	Nucleus matrix {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Tissue Specificity	Widely distributed in various tissues.
Top Pathways	Axon guidance, Fc gamma R-mediated phagocytosis, Pertussis, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Cofilin siRNA I - 6267 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Cofilin siRNA II - 6268 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Cofilin 1 CRISPR/Cas9 KO Plasmid (h) - sc-400394 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cofilin 1 HDR Plasmid (h) - sc-400394-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cofilin 1 Double Nickase Plasmid (h) - sc-400394-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cofilin 1 Double Nickase Plasmid (h2) - sc-400394-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cofilin 1 CRISPR Activation Plasmid (h) - sc-400394-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cofilin 1 CRISPR Activation Plasmid (h2) - sc-400394-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cofilin 1 Lentiviral Activation Particles (h) - sc-400394-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cofilin 1 Lentiviral Activation Particles (h2) - sc-400394-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Cofilin 1 siRNA (h) - sc-35078 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cofilin 1 shRNA Plasmid (h) - sc-35078-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Cofilin 1 shRNA (h) Lentiviral Particles - sc-35078-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN6006 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6006 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05343 from Sigma-Aldrich Category miRNA

CFL1 siRNA (Human) - CRH0773 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CFL1 - MBS8229927 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Cofilin 1 CRISPR/Cas9 KO Plasmid (h2) - sc-400394-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Cofilin 1 HDR Plasmid (h2) - sc-400394-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human CFL1 (NM_005507.2) - SHH262477 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CFL1(NM_005507.2) - SHG169461 from Creative biogene Category siRNA Species Reactivities Human

Human CFL1 siRNA - orb261275 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CFL1 shRNA Plasmid (Human) - CHH0773 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CFL1 miRNA 3'UTR clone - MiUTR1H-02077 from Creative biogene Species Reactivities Human

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