PIK3CA

Gene Symbol PIK3CA
Entrez Gene 5290
Alt Symbol CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Species Human
Gene Type protein-coding
Description phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Other Description PI3-kinase p110 subunit alpha|PI3K-alpha|phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha|phosphatidylinositol 3-kinase, catalytic, alpha polypeptide|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform|phosphoinositide-3-kinase, catalytic, alpha polypeptide|ptdIns-3-kinase subunit p110-alpha|serine/threonine protein kinase PIK3CA
Swissprots Q99762 P42336 Q14CW1
Accessions ADQ00185 ADQ00187 CAT16714 CAV28702 CDL93485 EAW78423 P42336 AB210020 BAE06102 AK021510 AK292940 BAF85629 AK297203 BAG59688 AK302608 BAG63856 AU129890 AW445128 BC113601 AAI13602 BC113603 AAI13604 BQ228953 BX437219 BX473473 BX484734 DQ910907 ABI95433 HM437241 ADN43072 U79143 AAB39753 Z29090 CAA82333 XM_006713658 XP_006713721 XM_011512894 XP_011511196 NM_006218 NP_006209
Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Reg
Top Pathways Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

PI3 Kinase p110α Antibody - 4255 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western Blot analysis of Jurkat cell extracts treated with LY294002 (PI3 Kinase Inhibitor) #9901 or Calyculin A #9902 using PI3 Kinase p110α Antibody.

PI3 Kinase p110α (C73F8) Rabbit mAb - 4249 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C73F8
Western blot analysis of extracts from HeLa cells and neonatal mouse brain using PI3 Kinase p110α (C73F8) Rabbit mAb.

PI3 Kinase p110 alpha Antibody - 4254 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

PI 3-kinase p110α (C-17) - sc-1331 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PI 3-kinase p110α (C-17): sc-1331. Immunoperoxidase staining of formalin fixed, paraffin-embedded human bronchus tissue showing cytoplasmic staining of respiratory epithelial cells.

PI 3-kinase p110α (H-201) - sc-7174 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PI 3-kinase p110α (H-201): sc-7174. Western blot analysis of PI 3-kinase p110α expression in Jurkat whole cell lysate.

PI 3-kinase p110α (N-20) - sc-1332 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PI 3-kinase p110α (N-20): sc-1332. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.

Anti-PI 3 Kinase catalytic subunit alpha antibody - ab71090 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab71090 stained DU145 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab71090 at 10µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PI 3 Kinase catalytic subunit alpha antibody - ab5453 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-PI 3 Kinase catalytic subunit alpha antibody - ab189205 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon tissue labeling PI 3 Kinase catalytic subunit alpha with ab189205 at 5 µg/ml.

Anti-PI 3 Kinase catalytic subunit alpha antibody - ab135958 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PI 3 Kinase catalytic subunit alpha antibody (ab135958) at 1/500 dilution + Mouse liver cell extract at 30 µg

Anti-PI 3 Kinase catalytic subunit alpha antibody [4F3] - ab126819 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4F3
Anti-PI 3 Kinase catalytic subunit alpha antibody [4F3] (ab126819) at 1/500 dilution + Recombinant Human PIK3CA protein (AA: 881-1068)

Anti-PI 3 Kinase catalytic subunit alpha antibody [EP383Y] - ab40776 from Abcam

Prices $99.00, $384.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP383Y
Anti-PI 3 Kinase catalytic subunit alpha antibody [EP383Y] (ab40776) at 1/5000 dilution + Jurkat cell lysate at 10 µg

Anti-PIK3CA / PI3K Alpha Antibody IHC-plus™ - LS-B8751 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PIK3CA / PI3K antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PIK3CA / PI3K Alpha Antibody (clone 4F3) - LS-C169164 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F3
Immunofluorescence of HeLa cells using PIK3CA mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.

Anti-PIK3CA / PI3K Alpha Antibody (aa303-631, clone 6D9) IHC-plus™ - LS-B12232 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 6D9
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-PIK3CA / PI3K Alpha Antibody (aa303-631, clone 8D6) - LS-C338535 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8D6
IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-PIK3CA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-PIK3CA / PI3K Alpha Antibody (Internal, clone SP139) - LS-C210378 from LifeSpan Bioscience

Prices $530.00
Sizes 500 µl
Host Rabbit
Clonality Monoclonal
Clone SP139
Immunohistochemistry of Human Prostate Adenocarcinoma stained with anti-PI3KCA antibody

Anti-PIK3CA / PI3K Alpha Antibody - LS-C38217 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CA / PI3K Alpha Antibody (aa511-541, AP) - LS-C266271 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CA / PI3K Alpha Antibody (clone 3G3) - LS-C197904 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G3
Detection limit for recombinant GST tagged PIK3CA is approximately 1 ng/ml as a capture antibody.

Anti-PIK3CA / PI3K Alpha Antibody (Internal) IHC-plus™ - LS-B5363 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PIK3CA antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5363 concentration 5 ug/ml.

Anti-PIK3CA / PI3K Alpha Antibody - LS-C192273 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of PIK3CA pAb in extracts from Jurkat cells.

Anti-PIK3CA / PI3K Alpha Antibody (aa511-541, APC) - LS-C266272 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CA / PI3K Alpha Antibody (aa511-541, Biotin) - LS-C266273 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CA / PI3K Alpha Antibody (aa511-541, FITC) - LS-C266274 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more