PIK3CB

Gene Symbol PIK3CB
Entrez Gene 5291
Alt Symbol P110BETA, PI3K, PI3KBETA, PIK3C1
Species Human
Gene Type protein-coding
Description phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Other Description PI3-kinase p110 subunit beta|PI3-kinase subunit beta|PI3K-beta|PtdIns-3-kinase p110|phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta|phosphoinositide-3-kinase, catalytic, beta polypeptide|ptdIns-3-kinase subunit beta|ptdIns-3-kinase subunit p110-beta
Swissprots D3DNF0 P42338 Q24JU2
Accessions CAC21449 CAD20430 EAW79053 EAW79054 EAW79055 EAW79056 P42338 AI623206 AK293754 BAG57175 AK302937 BAG64095 BC003393 AAH03393 BC022049 AAH22049 BC033948 BC035432 BC045790 BC114432 AAI14433 CR749357 CAH18210 S67334 AAB29081 XM_005247530 XP_005247587 XM_006713659 XP_006713722 XM_011512895 XP_011511197 XM_011512896 XP_011511198 NM_001256045 NP_001242974 NM_006219 NP_006210
Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21383062}. Nucleus {ECO:0000269|PubMed:21383062}. Note=Interaction with PIK3R2 is required for nuclear localization and export.
Tissue Specificity Expressed ubiquitously.
Top Pathways Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

Human PIK3CB / PI3K Beta ELISA Kit (Sandwich ELISA) - LS-F7528 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.156 ng/ml
Range 0.156-10 ng/ml

Human PIK3Cb ELISA Kit - abx152742 from Abbexa

Category ELISA Kit
Sensitivity 0.059 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide (PIK3Cb), Human, ELISA Kit - SEJ829Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.059ng/mL
Range 0.156-10ng/mL

PI3K (Phosphoinositide-3-Kinase), Human, ELISA Kit - E-EL-H1700 from ARP American Research Products

Category ELISA Kit
Prices $617.40
Sizes 96 t

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide, PIK3Cb, Human, ELISA Kit - E-EL-H1016 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL

Phosphotylinosital 3 kinase, PI3K, Mouse, ELISA Kit - E-EL-M0906 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Phosphotylinosital 3 Kinase, PI3K, Rat, ELISA Kit - E-EL-R0739 from ARP American Research Products

Category ELISA Kit
Prices $686.00
Sizes 96 t

Phosphoinositide-3-Kinase, PI3K, Rabbit, ELISA Kit - E-EL-RB1953 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide, PIK3Cb, Rabbit, ELISA Kit - E-EL-RB1861 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Phosphoinositide-3-Kinase, PI3K, Chicken, ELISA Kit - E-EL-Ch0531 from ARP American Research Products

Category ELISA Kit
Prices $504.00
Sizes 96 t

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide, PIK3Cb, Chicken, ELISA Kit - E-EL-Ch1219 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Phosphoinositide-3-Kinase, PI3K, Porcine, ELISA Kit - E-EL-P0871 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide, PIK3Cb, Porcine, ELISA Kit - E-EL-P1493 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Phosphoinositide-3-Kinase, PI3K, Sheep, ELISA Kit - E-EL-S0757 from ARP American Research Products

Category ELISA Kit
Prices $648.00
Sizes 96 t

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide, PIK3Cb, Sheep, ELISA Kit - E-EL-S0342 from ARP American Research Products

Category ELISA Kit
Prices $648.00
Sizes 96 t

Phosphoinositide-3-Kinase, PI3K, Guinea Pig, ELISA Kit - E-EL-GP0675 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Phosphoinositide-3-Kinase, PI3K, Monkey, ELISA Kit - E-EL-MK0867 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Phosphoinositide-3-Kinase Catalytic Beta Polypeptide, PIK3Cb, Monkey, ELISA Kit - E-EL-MK1602 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Phosphotylinosital 3 kinase (PI3K), ELISA Kit - MBS260381 from MyBioSource

Category ELISA Kit
Prices $290.00, $450.00, $1,755.00, $3,150.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.06 ng/ml.
Range 20 ng/ml-0.312 ng/ml

Phosphotylinosital 3 kinase (PI3K), ELISA Kit - MBS264501 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphotylinosital 3 kinase (PI3K), ELISA Kit - MBS268899 from MyBioSource

Category ELISA Kit
Prices $275.00, $420.00, $1,615.00, $2,880.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.06 ng/ml.
Range 20 ng/ml-0.312 ng/ml

Phosphotylinosital 3 kinase (PI3K), ELISA Kit - MBS263021 from MyBioSource

Category ELISA Kit
Prices $290.00, $450.00, $1,755.00, $3,150.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.05 ng/ml.
Range 10 ng/ml-0.156ng/ml

Phosphotylinosital 3 kinase (PI3K), ELISA Kit - MBS269681 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphotylinosital 3 kinase (PI3K), ELISA Kit - MBS2601844 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phosphotylinosital 3 kinase (PI3K), ELISA Kit - MBS267227 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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