PIK3CB

Gene Symbol PIK3CB
Entrez Gene 5291
Alt Symbol P110BETA, PI3K, PI3KBETA, PIK3C1
Species Human
Gene Type protein-coding
Description phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Other Description PI3-kinase p110 subunit beta|PI3-kinase subunit beta|PI3K-beta|PtdIns-3-kinase p110|phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta|phosphoinositide-3-kinase, catalytic, beta polypeptide|ptdIns-3-kinase subunit beta|ptdIns-3-kinase subunit p110-beta
Swissprots D3DNF0 P42338 Q24JU2
Accessions CAC21449 CAD20430 EAW79053 EAW79054 EAW79055 EAW79056 P42338 AI623206 AK293754 BAG57175 AK302937 BAG64095 BC003393 AAH03393 BC022049 AAH22049 BC033948 BC035432 BC045790 BC114432 AAI14433 CR749357 CAH18210 S67334 AAB29081 XM_005247530 XP_005247587 XM_006713659 XP_006713722 XM_011512895 XP_011511197 XM_011512896 XP_011511198 NM_001256045 NP_001242974 NM_006219 NP_006210
Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21383062}. Nucleus {ECO:0000269|PubMed:21383062}. Note=Interaction with PIK3R2 is required for nuclear localization and export.
Tissue Specificity Expressed ubiquitously.
Top Pathways Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

PI3 Kinase p110β (C33D4) Rabbit mAb - 3011 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C33D4
Western blot analysis of extracts from MCF-7 and K-562 cells using PI3 Kinase p110β (C33D4) Rabbit mAb.

PI 3-kinase p110 (D-4) - sc-8010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PI 3-kinase p110 (D-4): sc-8010. Western blot analysis of PI 3-kinase p110 expression in C32 whole cell lysate.

PI 3-kinase p110 (H-239) - sc-7189 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PI 3-kinase p110 (H-239): sc-7189. Western blot analysis of PI 3-kinase p110 expression in K-562 whole cell lysate.

PI 3-kinase p110 (I-19) - sc-7248 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PI 3-kinase p110β (H-198) - sc-7175 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PI 3-kinase p110β (H-198): sc-7175. Western blot analysis of PI 3-kinase p110β expression in K-562 whole cell lysate.

PI 3-kinase p110β (N-20) - sc-603 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of PI 3-kinase p110β expression in anti-phosphotyrosine immunoenriched K-562 whole cell lysates (A,B). Antibodies tested include PI 3-kinase p110β (S-19): sc-602 (A) and PI 3-kinase p110β (N-20): sc-603 (B).

PI 3-kinase p110β (S-19) - sc-602 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of PI 3-kinase p110β expression in anti-phosphotyrosine immunoenriched K-562 whole cell lysates (A,B). Antibodies tested include PI 3-kinase p110β (S-19): sc-602 (A) and PI 3-kinase p110β (N-20): sc-603 (B).

PI 3-kinase p85β (T15) - sc-56934 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PI 3-kinase p85β (T15): sc-56934. Western blot analysis of PI 3-kinase p85β expression in COLO 320DM (A), SW480 (B), HeLa (C) and U-87 MG (D) whole cell lysates.

Anti-PI3 Kinase p110 beta antibody - ab55593 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
PI3 Kinase p110 beta antibody (ab55593) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human lymph node.

Anti-PI3 Kinase p110 beta antibody - ab97322 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PI3 Kinase p110 beta antibody (ab97322) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-PI3 Kinase p110 beta antibody [EPR5515(2)] - ab151549 from Abcam

Prices $99.00, $387.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5515(2)
Overlay histogram showing SH-SY5Y cells stained with ab131260 (red line) at 1/20 dilution. The cells were fixed with 2% Paraformaldehyde. The secondary antibody used was a FITC conjugated goat anti-rabbit IgG at 1/150 dilution. Isotype control antibody (green line) was rabbit monoclonal IgG used under the same conditions.

Anti-PIK3CB / PI3K Beta Antibody (aa143-173, AP) - LS-C266276 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (aa143-173, APC) - LS-C266278 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB Antibody (N-Terminus, clone Y384) - LS-C49566 from LifeSpan Bioscience

Prices $480.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y384
Western blot analysis on Jurkat cell lysate using anti-PI3-kinase p110 subunit beta (N-term) antibody, dilution 1:500.

Anti-PIK3CB / PI3K Beta Antibody (aa143-173, FITC) - LS-C266280 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (aa143-173, Biotin) - LS-C266279 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (aa713-744) - LS-C99837 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with PI3KCB antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PIK3CB / PI3K Beta Antibody (aa143-173, PE) - LS-C266282 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (aa143-173, Azide-free, HRP) - LS-C266281 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (N-Terminus, Biotin) - LS-C266352 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (N-Terminus, APC) - LS-C266351 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (N-Terminus, AP) - LS-C266350 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (N-Terminus, Azide-free, HRP) - LS-C266354 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (N-Terminus, FITC) - LS-C266353 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3CB / PI3K Beta Antibody (Internal) IHC-plus™ - LS-B5359 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PIK3CB antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5359 concentration 5 ug/ml.
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