| Gene Symbol | PIK3CB |
|---|---|
| Entrez Gene | 5291 |
| Alt Symbol | P110BETA, PI3K, PI3KBETA, PIK3C1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
| Other Description | PI3-kinase p110 subunit beta|PI3-kinase subunit beta|PI3K-beta|PtdIns-3-kinase p110|phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta|phosphoinositide-3-kinase, catalytic, beta polypeptide|ptdIns-3-kinase subunit beta|ptdIns-3-kinase subunit p110-beta |
| Swissprots | D3DNF0 P42338 Q24JU2 |
| Accessions | CAC21449 CAD20430 EAW79053 EAW79054 EAW79055 EAW79056 P42338 AI623206 AK293754 BAG57175 AK302937 BAG64095 BC003393 AAH03393 BC022049 AAH22049 BC033948 BC035432 BC045790 BC114432 AAI14433 CR749357 CAH18210 S67334 AAB29081 XM_005247530 XP_005247587 XM_006713659 XP_006713722 XM_011512895 XP_011511197 XM_011512896 XP_011511198 NM_001256045 NP_001242974 NM_006219 NP_006210 |
| Function | Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21383062}. Nucleus {ECO:0000269|PubMed:21383062}. Note=Interaction with PIK3R2 is required for nuclear localization and export. |
| Tissue Specificity | Expressed ubiquitously. |
| Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |