| Gene Symbol |
G6PC
|
| Entrez Gene |
2538
|
| Alt Symbol |
G6PC1, G6PT, GSD1, GSD1a
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glucose-6-phosphatase, catalytic subunit
|
| Other Description |
G-6-Pase|G6Pase|G6Pase-alpha|glucose-6-phosphatase|glucose-6-phosphatase alpha
|
| Swissprots |
K7EL82 P35575 B4E1C3 A1L4C0
|
| Accessions |
AAD11621 CAA65638 EAW60901 EAW60902 P35575 AK303771 BAG64735 AK313982 BAG36695 AW614228 BC130478 AAI30479 BC136369 AAI36370 HQ258400 ADR83154 U01120 AAA16222 NM_000151 NP_000142 NM_001270397 NP_001257326
|
| Function |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein.
|
| Top Pathways |
Glucagon signaling pathway, AMPK signaling pathway, PI3K-Akt signaling pathway, Carbohydrate digestion and absorption, Glycolysis / Gluconeogenesis
|