C5AR1

Gene Symbol	C5AR1
Entrez Gene	728
Alt Symbol	C5A, C5AR, C5R1, CD88
Species	Human
Gene Type	protein-coding
Description	complement component 5a receptor 1
Other Description	C5a anaphylatoxin chemotactic receptor 1|C5a anaphylatoxin receptor|C5a ligand|C5a-R|complement component 5 receptor 1
Swissprots	P21730
Accessions	AAD14919 AAO65969 CAB37830 EAW57470 EAW57471 P21730 BC008982 AAH08982 BE042476 BI916506 BM830753 BT007358 AAP36022 DQ891757 ABM82683 DQ894940 ABM85866 M62505 AAA62831 X57250 CAA40530 XM_005259190 XP_005259247 XM_011527247 XP_011525549 NM_001736 NP_001727
Function	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12464600}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000269|PubMed:12464600}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269|PubMed:12464600}.
Top Pathways	Complement and coagulation cascades, Staphylococcus aureus infection, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Phospho-C5AR1 / CD88 / C5a Receptor (Ser338) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1763 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Human C5AR1 / CD88 / C5a Receptor ELISA Kit (Cell-Based ELISA) - LS-F1873 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse C5AR1 / CD88 / C5a Receptor ELISA Kit (Sandwich ELISA) - LS-F8506 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Complement C5a ELISA Kit - 55R-RE59292 from Fitzgerald Category ELISA Kit Prices $1,395.00 Sizes 96 wells

Human C5a ELISA Kit - abx150870 from Abbexa Category ELISA Kit Sensitivity 31 pg/ml Range 78.125 pg/ml - 5000 pg/ml

Complement Component 5a, C5a, Human, ELISA Kit - E-EL-H0190 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

C5a anaphylatoxin chemotactic receptor (C5AR1), Human, ELISA Kit - CSB-EL003996HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

C5a anaphylatoxin chemotactic receptor (C5AR1), Human, ELISA Kit - E01C1264 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

C5a, Human, ELISA - IB79153 from ARP American Research Products Category ELISA Kit Prices $1,076.00 Sizes 96 t Sensitivity < 0.02 ug/L Range 0 / 0.1 - 10 ug/L

Complement Component 5a (C5a), Human, ELISA Kit - SEA388Hu from ARP American Research Products Category ELISA Kit Prices $580.00 Sizes 96 t Sensitivity 31pg/mL Range 78-5,000pg/mL

Complement Component 5a, C5a, Mouse, ELISA Kit - E-EL-M0339 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Complement Component 5a, C5a, Rat, ELISA Kit - E-EL-R0257 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Complement Component 5a, C5a, Rabbit, ELISA Kit - E-EL-RB1225 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Complement Component 5a, C5a, Chicken, ELISA Kit - E-EL-Ch2256 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Complement Component 5a, C5a, Porcine, ELISA Kit - E-EL-P1794 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Complement Component 5a, C5a, Guinea Pig, ELISA Kit - E-EL-GP0337 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Complement Component 5a, C5a, Monkey, ELISA Kit - E-EL-MK1612 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Human C5a ELISA Kit - HC0670 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine C5a ELISA Kit - AC0670 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

CD88/C5aR Colorimetric Cell-Based ELISA Kit - CB5123 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

CD88/C5aR (Phospho-Ser338) Colorimetric Cell-Based ELISA - CBP1873 from Assay Biotechnology Category ELISA Kit Prices $450.00 Sizes 2 x 96 tests Range > 5000 Cells

Human C5a ELISA Kit - DEIA1748 from Creative Diagnostics Category ELISA Kit

Human C5a(Complement Component 5a) ELISA Kit - E-EL-H0190 from Elabscience Category ELISA Kit Sensitivity 46.88 pg/mL Range 78.13—5000 pg/mL

Human C5a (Complement Component 5a) CLIA Kit - E-CL-H0174 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

C5a, ELISA Kit - MBS2508582 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Rabbit C5a is 37.5pg/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 62.5-4000pg/mL

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