HBEGF

Gene Symbol	HBEGF
Entrez Gene	1839
Alt Symbol	DTR, DTS, DTSF, HEGFL
Species	Human
Gene Type	protein-coding
Description	heparin-binding EGF-like growth factor
Other Description	diphtheria toxin receptor (heparin-binding EGF-like growth factor)|diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)|heparin-binding epidermal growth factor|proheparin-binding EGF-like growth factor
Swissprots	B2R821 Q99075
Accessions	AAA50562 AAA50563 AAA50564 AAC15470 AAN46738 CAV28318 EAW62069 Q99075 AK222688 BAD96408 AK307310 AK313202 BAG36018 BC033097 AAH33097 D55114 EU832647 ACE87738 EU832724 ACE87056 M60278 AAA35956 NM_001945 NP_001936
Function	Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Subcellular Location	Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.
Top Pathways	GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse HBEGF / HB EGF ELISA Kit (Sandwich ELISA) - LS-F5901 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 5.7 pg/ml Range 16.38-1600 pg/ml

Human HBEGF / HB EGF ELISA Kit (Sandwich ELISA) - LS-F2675 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 7.8 pg/ml Range 16.38-1600 pg/ml

Human HBEGF / HB EGF ELISA Kit (Sandwich ELISA) - LS-F4629 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 5.8 pg/ml Range 16.38-1600 pg/ml

Rat HBEGF / HB EGF ELISA Kit (Sandwich ELISA) - LS-F5856 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 16.38-1600 pg/ml

Human HBEGF / HB EGF ELISA Kit (Sandwich ELISA) - LS-F99 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 16.38 pg/ml Range 16.38-1600 pg/ml

Human HBEGF / HB EGF ELISA Kit (Sandwich ELISA) - LS-F11606 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 31.2 Range 16.38-1600 pg/ml

Human HB-EGF ELISA Kit - RAB0211 from Sigma-Aldrich Category ELISA Kit Prices $629.00 Sizes 1 kt

Human HB-EGF DuoSet ELISA, 15 Plate - DY259 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Human HBEGF ELISA Kit - abx151776 from Abbexa Category ELISA Kit Sensitivity 5.8 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Human HBEGF ELISA Kit - abx056183 from Abbexa Category ELISA Kit

Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF), Human, ELISA Kit - SEB479Hu from ARP American Research Products Category ELISA Kit Prices $580.00 Sizes 96 t Sensitivity 6.3pg/mL Range 15.6-1,000pg/mL

Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF), Human, ELISA Kit - PB-0770 from ARP American Research Products Category ELISA Kit Prices $418.00 Sizes 96 t Sensitivity < 10 pg/ml Range 15.6pg/ml-1000pg/ml

Heparin-binding EGF-like growth factor (HBEGF), Human, ELISA Kit - E01H1364 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Heparin-binding epidermal growth factor-like growth factor, HB-EGF, Human, ELISA Kit - CSB-E09716h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

Proheparin-binding EGF-like growth factor, HBEGF, Human, ELISA Kit - E1479h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 31.2-2000 pg/mL

Heparin Binding Epidermal Growth Factor Like Growth Factor, HBEGF, Rat, ELISA Kit - E-EL-R0493 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF), Human, CLIA Kit - SCB479Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 10.4pg/mL Range 31.2-2,000pg/mL

Human HB-EGF ELISA - ELH-HBEGF from RayBiotech Category ELISA Kit Prices $560.00, $1,008.00, $2,241.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 20 pg/ml Range 20 pg/ml - 4000 pg/ml

Anserine HBEGF ELISA Kit - AH0045 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

HBEGF, ELISA Kit - MBS176521 from MyBioSource Category ELISA Kit Prices $425.00 Sizes 1x96 wells Sensitivity < 10pg/ml Range 15.6pg/ml-1000pg/ml

HBEGF, ELISA Kit - MBS824799 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 15.6 pg/ml - 1000 pg/ml

heparin binding EGF like growth factor (HBEGF), ELISA Kit - MBS7226992 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

heparin-binding EGF-like growth factor, ELISA Kit - MBS283523 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

heparin-binding EGF-like growth factor, ELISA Kit - MBS704504 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

heparin-binding EGF-like growth factor (HBEGF), ELISA Kit - MBS7220748 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 mg/L.

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