HBEGF

Gene Symbol HBEGF
Entrez Gene 1839
Alt Symbol DTR, DTS, DTSF, HEGFL
Species Human
Gene Type protein-coding
Description heparin-binding EGF-like growth factor
Other Description diphtheria toxin receptor (heparin-binding EGF-like growth factor)|diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)|heparin-binding epidermal growth factor|proheparin-binding EGF-like growth factor
Swissprots B2R821 Q99075
Accessions AAA50562 AAA50563 AAA50564 AAC15470 AAN46738 CAV28318 EAW62069 Q99075 AK222688 BAD96408 AK307310 AK313202 BAG36018 BC033097 AAH33097 D55114 EU832647 ACE87738 EU832724 ACE87056 M60278 AAA35956 NM_001945 NP_001936
Function Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Subcellular Location Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.
Top Pathways GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Proteoglycans in cancer

HB-EGF CRISPR/Cas9 KO Plasmid (h) - sc-400795 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HB-EGF HDR Plasmid (h) - sc-400795-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HB-EGF Double Nickase Plasmid (h) - sc-400795-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HB-EGF Double Nickase Plasmid (h2) - sc-400795-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HB-EGF CRISPR Activation Plasmid (h) - sc-400795-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HB-EGF CRISPR Activation Plasmid (h2) - sc-400795-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HB-EGF Lentiviral Activation Particles (h) - sc-400795-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HB-EGF Lentiviral Activation Particles (h2) - sc-400795-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HB-EGF siRNA (h) - sc-39420 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HB-EGF shRNA Plasmid (h) - sc-39420-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HB-EGF shRNA (h) Lentiviral Particles - sc-39420-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HB-EGF RNAi - H00001839-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU001581 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9897 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9897 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09308 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09308

HBEGF siRNA (Human) - CRH1287 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HBEGF - MBS8240155 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HB-EGF CRISPR/Cas9 KO Plasmid (h2) - sc-400795-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HB-EGF HDR Plasmid (h2) - sc-400795-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human HBEGF (NM_001945.2) - SHH310617 from Creative biogene

Category siRNA
Species Reactivities Human

HBEGF shRNA Plasmid (Human) - CHH1287 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HBEGF miRNA 3'UTR clone - MiUTR3H-00674 from Creative biogene

Species Reactivities Human
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