| Gene Symbol |
MAPK3
|
| Entrez Gene |
5595
|
| Alt Symbol |
ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase 3
|
| Other Description |
MAP kinase isoform p44|MAPK 1|extracellular signal-regulated kinase 1|extracellular signal-related kinase 1|insulin-stimulated MAP2 kinase|microtubule-associated protein 2 kinase
|
| Swissprots |
Q8NHX1 P27361 A8CZ58 B0LPG3
|
| Accessions |
ABY87542 AGC09597 CBK51145 EAW79912 EAW79913 EAW79914 EAW79915 EAW79916 EAW79917 P27361 AK091009 BAG52261 AK307995 AY033607 AAK52329 AY033608 AAK52330 BC000205 AAH00205 BC013992 AAH13992 BX537897 CAD97888 DA351318 DQ399291 ABD60302 DQ893440 ABM84366 DQ896778 ABM87777 KJ534878 AHW56518 M84490 AAA36142 X60188 CAA42744 Z11696 CAA77754 XR_243293 NM_001040056 NP_001035145 NM_001109891 NP_001103361 NM_002746 NP_002737
|
| Function |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization.
|
| Top Pathways |
TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion
|
![Western Blot: ERK1 Overexpression Lysate (Adult Normal) [NBL1-12877] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ERK1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8328_ERK1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12877-img0002.jpg)