GABBR1

Gene Symbol GABBR1
Entrez Gene 2550
Alt Symbol GABABR1, GABBR1-3, GB1, GPRC3A, dJ271M21.1.1, dJ271M21.1.2
Species Human
Gene Type protein-coding
Description gamma-aminobutyric acid (GABA) B receptor, 1
Other Description GABA-BR1|GABAB, subunit 1c|gamma-aminobutyric acid type B receptor subunit 1|seven transmembrane helix receptor
Swissprots Q5SUJ8 Q5STL4 Q9UQQ0 Q86W60 Q5SUL3 O95375 Q9UBS5 O95975 O96022 O95468 B0UXY7 Q71SG6
Accessions BAC05730 CAA09031 CAA21453 CAA21454 CAI79356 EAX03205 EAX03206 EAX03207 EAX03208 EAX03209 EAX03210 EAX03211 EAX03212 Q9UBS5 AB208790 BAD92027 AF099148 AAC98508 AF301005 AAG23962 AJ012185 CAA09939 AJ012186 CAA09940 AJ012187 CAA09941 AJ012288 CAA09980 AJ225028 CAA12359 AJ225029 CAA12360 AK223619 BAD97339 AK290191 BAF82880 AK312308 BAG35233 BC023336 BC041332 AAH41332 BC042598 AAH42598 BC050532 AAH50532 DA112662 DA400111 Y11044 XM_005248982 XP_005249039 XM_005272785 XP_005272842 XM_005274841 XP_005274898 XM_005274931 XP_005274988 XM_005275088 XP_005275145 XM_005275227 XP_005275284 XM_005275363 XP_005275420 XM_006715047 XP_006715110 XM_006725030 XP_006725093 XM_006725477 XP_006725540 XM_006725691 XP_006725754 XM_006725807 XP_006725870 XM_006725901 XP_006725964 XM_006725988 XP_006726051 XM_011514453 XP_011512755 XM_011514454 XP_011512756 XM_011514455 XP_011512757 XM_011514456 XP_011512758 XM_011546282 XP_011544584 XM_011546283 XP_011544585 XM_011546284 XP_011544586 XM_011547197 XP_011545499 XM_011547198 XP_011545500 XM_011547199 XP_011545501 XM_011547200 XP_011545502 XM_011547611 XP_011545913 XM_011547612 XP_011545914 XM_011547613 XP_011545915 XM_011547614 XP_011545916 XM_011547848 XP_011546150 XM_011547849 XP_011546151 XM_011548017 XP_011546319 XM_011548018 XP_011546320 XM_011548019 XP_011546321 XM_011548020 XP_011546322 XM_011548206 XP_011546508 XM_011548207 XP_011546509 XM_011548208 XP_011546510 XM_011548209 XP_011546511 XR_241884 XR_246960 XR_247352 XR_247386 XR_247400 XR_430672 XR_430972 NM_001470 NP_001461 NM_021903 NP_068703 NM_021904 NP_068704 NM_021905
Function Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conduct
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. {ECO:0000250}.
Tissue Specificity Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. {ECO:0000269|PubMed:9844003}.
Top Pathways GABAergic synapse, Morphine addiction, Estrogen signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction

GABA(B)R1 Antibody - 3835 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, co-transfected with constructs overexpressing GABA(B)R1 and GABA(B)R2, and mouse and rat brain using GABA(B)R1 Antibody.

GABA B R1 (R-20) - sc-7338 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABA<sub>B</sub> R1 (R-20): sc-7338. Western blot analysis of GABA<sub>B</sub> R1 expression in non-transfected: sc-117752 (A) and human GABA<sub>B</sub> R1 transfected: sc-116203 (B) 293T whole cell lysates.

GABA B R1 (D-2) - sc-166408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GABA<sub>B</sub> R1 (D-2): sc-166408. Western blot analysis of GABA<sub>B</sub> R1 expression in non-transfected: sc-117752 (A) and human GABA<sub>B</sub> R1 transfected: sc-116203 (B) 293T whole cell lysates.

GABA B R1 (R-300) - sc-14006 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GABA<sub>B</sub> R1 (R-300): sc-14006. Western blot analysis of rat recombinant GABA<sub>B</sub> R1 fusion protein.

GABA B R1 (S-20) - sc-7339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GABA B R1α (A-19) - sc-7340 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABA<sub>B</sub> R1α (A-19): sc-7340. Western blot analysis of GABA<sub>B</sub> R1α expression in IMR-32 (A), SH-SY5Y (B) and H4 (C) whole cell lysates.

p-GABA B R1 (Ser 923) - sc-135694 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
p-GABA<sub>B</sub> R1 (Ser 923): sc-135694. Western blot analysis of GABA<sub>B</sub> R1 phosphorylation in untreated (A) and lambda protein phosphatase-treated (B) rat synaptic membrane tissue extracts.

Anti-GABA B Receptor 1 antibody - ab55051 from Abcam

Prices $398.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GABA B Receptor 1 antibody - ab131417 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GABA B Receptor 1 antibody (ab131417) at 1/500 dilutionLane 1 : Mouse brain tissue lysateLane 2 : Rat brain tissue lysate

Anti-GABA B Receptor 1 antibody - ab75239 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GABA B Receptor 1 antibody (ab75239) at 1/500 dilutionLane 1 : extracts from K562 cellsLane 2 : extracts from K562 cells with immunizing peptide at 5 µgLysates/proteins at 15 µg per lane.

Anti-GABA B Receptor 1 antibody - ab137437 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-GABA B Receptor 1 antibody (ab137437) at 1/500 dilution + C8D30 whole cell lysate/extract at 30 µg

Anti-GABA B Receptor 1 antibody [EPR9404] - ab166604 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9404
All lanes : Anti-GABA B Receptor 1 antibody [EPR9404] (ab166604) at 1/1000 dilutionLane 1 : Fetal brain lysateLane 2 : U87-MG lysateLane 3 : HeLa lysateLane 4 : SH-SY5Y lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-GABA B Receptor 1 antibody [S93A-49] - ab134314 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa873-977, clone S93A-49, Atto 488) - LS-C228642 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa873-977, clone S93A-49, Atto 565) - LS-C228644 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa873-977, clone S93A-49, Atto 390) - LS-C228643 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa873-977, clone S93A-49, Atto 594) - LS-C228645 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49

Anti-GABBR1 / GABA B Receptor 1 Antibody (clone S93A-49) - LS-C150476 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49
Western blot analysis of GABA(Beta)R1 in rat brain membrane tissues, using a 1:1000 dilution of GABABR1 / GABBR1 antibody.

Anti-GABBR1 / GABA B Receptor 1 Antibody (Pro931) - LS-C177155 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of GABAB R1 (P931) pAb in extracts from K562 cells.

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa871-920) - LS-C118454 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using GABA-B Receptor Antibody. The picture on the right is treated with the synthesized peptide.

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa873-977, clone S93A-49, Atto 655) - LS-C228647 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa873-977, clone S93A-49, Atto 680) - LS-C228648 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa873-977, clone S93A-49, Atto 633) - LS-C228646 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa873-977, clone S93A-49, Atto 700) - LS-C228649 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49

Anti-GABBR1 / GABA B Receptor 1 Antibody (aa873-977, clone S93A-49, AP) - LS-C228650 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S93A-49
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